观赏獐牙菜中新酮的化学研究  

Chemical studies on new xanthone from Swertia decora

作　　者：肖怀[1] 陆阳[1] 陈泽乃[1] 刘光明[2] 钱金木伏 

机构地区：[1]上海第二医科大学化学教研室,上海200025 [2]大理医学院药学系,云南大理671000

出　　处：《中国药学杂志》2001年第5期302-304,共3页Chinese Pharmaceutical Journal

摘　　要：目的　研究我国民族药观赏獐牙菜 (SwertiadecoraFranch)的化学成分。方法　用常规的硅胶柱层析和薄层色谱法进行分离 ,根据化合物的理化性质及一维、二维波谱解析鉴定其结构。结果　从观赏獐牙菜脂溶性部分得到 6个化合物 ,分别鉴定为 1 羟基 4,5 ,6 ,7 四甲氧基酮 (swertiadecoraxanthone Ⅰ ) (Ⅰ ) ;1,3,8 三羟基 2 ,5 二甲氧基酮 (Ⅱ ) ;1,8 二羟基 3,7 二甲氧基酮 (methylswertianin ,Ⅲ ) ;1 羟基 3 ,7,8 三氧甲基酮 (decussatin ,Ⅳ ) ;1,7,8 三羟基 3 甲氧基酮 (swertianin ,Ⅴ )及二十四烷酸 (tetracosanoicacidⅥ )。结论　化合物Ⅱ为新化合物 ,定名为观赏獐牙菜酮 Ⅱ (swertiadecoraxanthone Ⅱ ) 。OBJECTIVE To study the chemical constituents of Swertia decora Franch,a traditional herb medication in China.METHODS The constituents were separated and purified by using column chromatography with silica gel.Their structures were identified on the basis of spectral analysis and chemical reactions.RESULTS Six compounds were isolated from the CHCl 3 part of the extracts.Their structures were determined as 1 hydroxy 4,5,6,7 tetramethoxyxanthone(swertiadecoraxanthone Ⅰ)(Ⅰ),1,3,8 trihydroxy 2,5 dimethoxyxanthone(Ⅱ),1,8 dihydroxy 3,7 dimethoxy xanthone (methylswertianin,Ⅲ),1 hydroxy 3,7,8 trimethoxyxanthone (decussatin,Ⅳ),1,7,8 trihydroxy 3 methoxyxanthone(swertianin,Ⅴ) and tetracosanoic acid(Ⅵ),respectively.CONCLUSION Ⅱ named as swertiadecoraxanthone Ⅱ was a new compound and the others were found from this plant for the first time.

关 键 词：观赏獐牙菜 龙胆科 SHAN酮 观赏獐牙菜Shan酮-Ⅱ 化学成分 

分 类 号：R284.1[医药卫生—中药学]