二乙酰基莲心碱抗实验性心律失常的作用  

Antiarrhythmic effect of diacetyl-linesinine

作　　者：王辉[1] 罗顺德[1] 蔡鸿生 王芳[1] 杨健[1] 

机构地区：[1]武汉大学人民医院,湖北武汉430060

出　　处：《中国医院药学杂志》2001年第6期328-330,共3页Chinese Journal of Hospital Pharmacy

基　　金：湖北省自然科学基金资助课题;编号SJ-98B78

摘　　要：目的：研究二乙酰基莲心碱抗心律失常的药理作用。方法：采用乌头碱、哇巴因、氯化钙3种抗心律失常模型。结果：二乙酰基莲心碱5 mg·kg-1 iv可明显提高乌头碱致大鼠、哇巴因致豚鼠发生室性早 搏、室性心动过速、室颤及心脏停搏用量；延长氯化钙诱发大鼠心律失常的出现时间，减少 早搏、室颤的发生率及死亡率。结论：二乙酰基莲心碱具有广泛的抗心律失常作用。：OBJECTIVE To study the effect of diacetyl-linesinine on arrhythmias. METHODS Effect of diacetyl-linesinine on arrhythmia was observed in three models- aconitine,ouabain and CaCl2 induced experimental arrhythmias. RESULTS Diacetyl-linesinine 5 mg·kg-1 could increase the threshold dose of ventr icular ectopia(VE),ventricular tachyacardia(VF),ventricular fibrillation and c ardiac arrest(CA) caused by aconitine in rats and that by ouabain in ginuea pigs ;delay the onset time of arrhythmia and decrease the incidence of VE,VF and CA i nduced by CaCl2 in rats. CONCLUSIONS Diacetyl-linesinine possesses entensive antiarrhythmic effects.

关 键 词：二乙酰基莲心碱 心律失常 乌头碱 哇巴因 氯化钙 药物治疗 

分 类 号：R972.2[医药卫生—药品] R541.7[医药卫生—药学]