美托洛尔和苯那普利对急性心肌梗死患者心率变异性的影响  

Effect of metoprolol and benazepril on heart rate variability in acute myocardial infarction patients

作　　者：付军[1] 白旭东[1] 孙录[2] 门正昆 张华[3] 周展[3] 

机构地区：[1]吉林大学第一医院,吉林长春130021 [2]吉林大学中日联谊医院 [3]沈阳市第十人民医院

出　　处：《中国老年学杂志》2001年第4期246-248,共3页Chinese Journal of Gerontology

摘　　要：目的　评价美托洛尔和苯那普利对急性心肌梗死 (AMI)患者心率变异性的影响。方法　无合并症的 AMI患者共 49例 ,1 5例为美托洛尔组 ,1 5例为苯那普利组 ,1 9例为安慰剂组 ,于心肌梗死后 5～ 7d及治疗 30 d后行 2 4 h动态心电图检查 ,观察心率变异性的时域指标和频域指标的变化。结果　心肌梗死各组的心率变异性明显减低 ,美托洛尔和苯那普利治疗后 ,心率变异性的时域指标和频域指标均明显改善。结论　美托洛尔和苯那普利可以明显改善无合并症? Objective To evaluate the effect of metoprolol and benazepril on heart rate variability(HRV) in acute myocardial infarction(AMI) patients.Methods 49 patients with uncomplicated AMI were studied.There were metoprolol group(15 patients),Benazepril group(15 patients) and the placebo group(19 patients).5～7 days after AMI and 30 days after treatment,the patients were undergone 24 hour ambulatory electrocardiogram monitoring and investigated the change of HRV time domain and frequency domain indexes.Results The HRV of infarction groups were significantly decreased.The HRV time domain and frequency domain indexes after treatment with metoprolol and benazepril were significantly improved.Conclusions Metoprolol and benazepril can significantly improve the HRV of uncomplicated acute myocardial infarction patients.

关 键 词：心率变异性 急性心肌梗死 美托洛尔 苯那普利 药物疗法 

分 类 号：R542.220.5[医药卫生—心血管疾病]