黄连素对灌流心脏发生心衰的保护作用  

Protective Effect of Berberine on Isolated Perfused Heart in Heart Failure

作　　者：周祖玉[1] 徐建国[1] 蓝庭剑[1] 

机构地区：[1]华西医科大学基础医学院生理教学研室,成都610041

出　　处：《华西医科大学学报》2001年第3期417-418,共2页Journal of West China University of Medical Sciences

基　　金：四川省科委科研基金资助 (批准号 970 14 )

摘　　要：目的　探讨黄连素对心脏衰竭的发生有无保护作用。方法　采用 L angendorff法灌流离体心脏 ,用维那帕米造成急性心衰 ;比较用黄连素和不用黄连素的心脏心衰程度的差异。结果　用黄连素 (10 - 6 mol/ L)灌流心脏后再用维那帕米致衰 ,此时心衰发生的程度明显轻于未用黄连素组 (P<0 .0 0 1)。Objective To examine the protective action of berberine against the development of heart failure. Methods Wister rats were divided into two groups. The Langendorff perfusion of isolated heart was performed and Verapamil was used to bring about acute heart failure. The experiment group was given berberine (10 -6 mol/L) before the use of Verapamil, but the control group was not given the berberine. A comparison was made on the degree of heart failure between the two group.Results The degree of heart failure in the experiment group was significantly less severe than that in the control group ( P <0.001). Conclusion Berberine has the protective action against to the development of heart failure.

关 键 词：黄连素 心力衰竭 保护作用 大鼠 

分 类 号：R541.61[医药卫生—心血管疾病]