^(153)Sm-EDTMP骨摄取率测定及其与疗效的关系  

The Measurement of ^(153)Sm EDTMP Bone Uptake Rate and Its Relationship with Therapeutic Effect

作　　者：李林[1] 梁正路[1] 邓候富[1] 李云春[1] 张锡英[1] 杨晓川[1] 

机构地区：[1]华西医科大学附属第一医院核医学科,成都610041

出　　处：《华西医科大学学报》2001年第3期446-448,共3页Journal of West China University of Medical Sciences

摘　　要：目的　采用全身显像法测定 1 5 3 Sm- EDTMP(乙二胺四甲撑膦酸 )骨摄取率 ,并探讨骨摄取率与疗效之间的关系。方法　使用 Elscint双探头 γ相机 ,于注射 1 5 3 Sm- EDTMP后 10分钟和 6小时 ,对 66例骨转移癌患者进行全身显像并测定骨摄取率。结果　 66例患者全身显像法测定的骨摄取率范围在 31.9%～ 86.6%之间 ,平均5 6.0 % ,1 5 3 Sm- EDTMP骨摄取率高的患者的总体疗效好于骨摄取率低的患者。根据显像法测定的骨摄取率 ,以红骨髓吸收剂量限制在 140 0 m Gy为标准进行个体化给药 ,66例患者所接受的治疗剂量在 1.40～ 2 .2 7GBq之间 (平均 1.90 GBq) ,骨髓吸收剂量在 1370～ 1430 m Gy之间 (平均 140 0 m Gy)。结论　通过测定 1 5 3 Sm- EDTMP进行安全而有效的个体化给药 ,在达到治疗效果的同时 ,避免了骨髓毒性反应的发生 。Objective To evaluate the measurement of 153 Sm EDTMP Bone uptake rate with whole body scintigraphy and analyze the relationship between bone uptake rate and therapeutic effect. Methods 66 patients with bony metastases were examined with whole body scintigraphy 10 minutes and 6 hours after the administration of 153 Sm EDTMP, and then bone uptake rate was calculated. Results The bone uptake rate in 66 patients ranged from 31.9% to 86.6%, (mean 56.0%). The patients with higher bone uptake rate had better overall therapeutic effect. According to the bone uptake rate calculated by whole body scintigraphy, the therapy activity administered within the limit of bone marrow absorbed dose of 1400 mGy in these patients was 1.40 2.27GBq (mean 1.90 GBq). Conclusion The present authors have developed a whole body scintigraphic technique which is simple and reliable in calculating prospectively a safe and effective dose of 153 Sm EDTMP for palliating the patient's painful bone metastases without myelotoxicity.

关 键 词：乙二胺四甲撑膦酸 治疗剂量 全身显像 骨摄取率 骨髓毒性反应 骨转移癌 

分 类 号：R817.4[医药卫生—影像医学与核医学]