急性中毒患者血浆内皮素测定的临床价值  

The clinical value of determination of plasma endothelin in patients with acute intoxication

作　　者：张康信[1] 郑辉[1] 陈荣健[1] 林惠文[1] 卢伟明 

机构地区：[1]广东省江门市中心医院 [2]江门市人民医院,529070

出　　处：《中国实用内科杂志》2001年第5期278-279,共2页Chinese Journal of Practical Internal Medicine

基　　金：1999年江门市科研立项攻关课题

摘　　要：目的　研究急性中毒患者血浆内皮素浓度的临床价值。方法用放免和比色法测定６０例急性中毒患者血浆内皮素的浓度与正常对照组对比分析。结果轻度急性中毒患者血浆内皮素轻度升高，但无显著差异（Ｐ＞０．０５）；中度中毒患者明显升高（Ｐ＜０．０１）；重度中毒显著升高（Ｐ＜０．０１）。结论急性中毒患者中毒越重血浆内皮素升高越明显，可作为判断病情轻重和预后的一个重要指标。如何抑制血浆内皮素增加，对提高抢救急性中毒的成功率，减少病死率有一定的临床研究价值。Objective To study the clinical value of concentration of plasma endothelin for patients with acute intoxication. Methods The concentrations of plasma endothelin were determined in 60 cases of patients with acute intoxication by radio - immunity or chromometry and compared with normal control group' s. Results Among patients with acute intoxication, concentration of plasma endothelin increased slightly at mild intoxication but no significant difference(P >0. 05 ),while it increased markedly at moderate intoxication(P < 0. 01 ) and very markedly at severe intoxication(P <0. 01 ). Conclusions The more severe intoxication, the higher concentration Of plasma endothelin and this may be an important marker to judge the seventy or prognosis of patients with acute intoxication. It has some value of clinical investigation in how to restrain the increasing of plasma endothelin thereby to increase the successful rate of resuscitation and decrease the mortality rate in patients with acute intoxication.

关 键 词：内皮素 急性中毒 多器官功能衰竭 

分 类 号：R595[医药卫生—内科学]