胆囊结石患者血浆、胆汁及胆囊组织中胃动素和血管活性肠肽的变化及意义  

CHANGES AND ITS SIGNIFICANCE OF MOTILIN, VASOACTIVE INTESTINAL PEPTIDE IN PLASMA, GALLBLADDER TISSUS AND BILE IN PATIENTS WITH GALLSTONE DISEASE

作　　者：周文[1] 杨进清[2] 文亚渊[3] 王代科[3] 徐有奇[1] 金世龙[3] 

机构地区：[1]第三军医大学大坪医院野战外科研究所核医学科,重庆400042 [2]第三军医大学大坪医院野战外科研究所病理科 [3]第三军医大学大坪医院野野战外科研究所普通外科

出　　处：《中国普外基础与临床杂志》2001年第3期171-172,186,共3页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的探讨胃动素（ＭＯＴ）及血管活性肠肽（ＶＩＰ）与胆囊结石形成的关系。方法收集 ４８例胆囊结石患者术前及术后１、３、７天血浆和胆囊组织、胆汁，采用放射免疫法测定其ＭＯＴ和ＶＩＰ含量。结果胆囊结石患者术前及术后血浆ＭＯＴ水平明显升高；胆囊组织及胆汁中ＭＯＴ、ＶＩＰ水平均明显升高，且胆囊组织中ＭＯＴ与ＶＩＰ呈明显正相关。结论ＭＯＴ和ＶＩＰ可能通过改变胆囊的运动而促进了胆囊结石的形成。Objective To discuss the relationship between motilin, vasoactive intestinal peptide and the gallstone formation. Methods The level of motilin, vasoactive intestinal peptide in plasma. bile and gallbladder tissue of 48 cases of chololithiasis before operation and the first, third, seventh day after cholecystectomy were mesured by radioimmunoassay. Results The level of motilin in plasma was markedly increased in patients with chololithiasis before cholecystectomy and the first day after cholecystectomy The level of motilin, vasoactive intestinal peptide in bile and gallbladder tissue were significantly increased in patients and motilin was positively correlated with vasoactive intestinal peptide in the gallbladder tissue. Conclusion Motilin, vasoactive intestinal peptide might affect the gallstone formation by affecting the motility of gallbladder.

关 键 词：胆囊结石 血浆 胆汁 胆囊组织 胃动素 血管活性肠肽 

分 类 号：R657.42[医药卫生—外科学]