卡托普利对糖尿病大鼠坐骨神经结构和功能的影响  

Effects of Captopril on structure and function of sciatic nerve in diabetic rats

作　　者：隋国良[1] 刘国庆[1] 董砚虎[1] 

机构地区：[1]山东省潍坊医学院内分泌研究室

出　　处：《中华内分泌代谢杂志》2001年第4期246-249,共4页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的　研究卡托普利对糖尿病大鼠坐骨神经结构和功能的影响。方法　对链脲佐菌素诱导的糖尿病大鼠模型 ,予以卡托普利治疗 12周 ,观察其对坐骨神经糖化终产物、环磷酸腺苷(cAMP)、神经传导速度及神经结构的影响。结果　卡托普利可降低坐骨神经中糖化终产物含量 ,提高神经组织中cAMP的含量 ,部分改善坐骨神经传导速度 ,减轻神经的病理改变。结论　卡托普利可通过降低糖基化终产物的含量 ,增加神经组织cAMP的生成 。Objective To investigate the effects of captopril on structure and function of sciatic nerve in diabetic rats. Methods Streptozotocin induced diabetic male Sprague Dawley rats were treated with 0.1% captopril in drinking water for 12 weeks, then advanced glycation end products (AGEs), cAMP content, and the nerve conduction velocity of sciatic nerve in diabetic rats were measured, morphometric quantitative analysis and ultrastructure of sural nerve were also performed. Results Captopril reduced accumulation of AGEs, restored synthesis of cAMP in sciatic nerve, improved nerve conduction velocity partialy, and ameliorated morphology abnormalities in myelin nerve fibre. Conclusion These findings suggest that captopril may exert a therapeutic effects on diabetic peripheral neuropathy.

关 键 词：实验性糖尿病 卡托普利 坐骨神经 大鼠 

分 类 号：R587.2[医药卫生—内分泌] R745.42[医药卫生—内科学]