先天性心脏病儿童白细胞介素2活性及膜表面白细胞介素2受体的研究  

The Study about Activity of Interleukin-2 and Membrane Interleukin-2 Receptor in Children with Congenital Heart Disease

作　　者：饶智国[1] 黄显湘[2] 李佩玲[2] 

机构地区：[1]广州军区武汉总医院儿科,湖北武汉430070 [2]华中科技大学协和医院儿科,湖北武汉430022

出　　处：《咸宁医学院学报》2001年第2期105-106,共2页Journal of Xianning Medical College

摘　　要：目的研究先天性心脏病 (先心病 )患儿的免疫功能状态。方法采用间接免疫荧光法检测膜表面白细胞介素 2受体 (Tac)、植物血凝素刺激后的膜表面白细胞介素 2受体 (Tac a) ,MTT比色法检测白细胞介素 2活性 (IL -2 )。结果与健康儿童比较 ,先心病患儿IL -2活性和Tac a都显著降低 (P <0 .0 1 ) ;与非紫绀型先心病患儿比较 ,紫绀型先心病患儿IL -2活性显著降低 (P <0 .0 1 )。结论先心病患儿免疫功能缺陷可能是其易患感染性疾病的原因之一 。Objective To investigate the immune function of children with congenital heart disease(CHD).Methods With the method of indirect immunoflurescence and MTT colormetric assay,interleukin 2 receptor (IL 2R,Tac),Tac exposed to phytahematoagglutinin(PHA) (Tac a) and the activity of interleukin 2(IL 2) of 32 cases with CHD were tested.Results The Tac a and IL 2 decreased in both groups of cyanotic and acyanotic CHD compared with normal control subjects(NC)(P&lt;0.01);compared with acyanotic CHD,IL 2 decreased also in cyanotic CHD.Conclusion The immunodeficiency of children with CHD is probably one factor of susceptibility to infection.It indicated that it is necessary to prevent infection by enhancing immune function of children with CHD.

关 键 词：先天性心脏病 儿童 白细胞介素2 活性 白细胞介素2受体 

分 类 号：R725.411[医药卫生—儿科]