运脾复方对幼龄厌食大鼠下丘脑外侧区和腹内侧区神经元自发放电的影响  

EFFECTS OF YUNPI FUFANG ON THE SPONTANEOUS DISCHARGES OF NEURONS IN LH AND VMH OF JUVENILE RAT WITH ANOREXIA

作　　者：杜永平[1] 张月萍[2] 胡三觉[3] 汪受传[4] 

机构地区：[1]第四军医大学西京医院中医科,西安710032 [2]第四军医大学西京医院小儿科 [3]第四军医大学西京医院神经科学研究所,西安710032 [4]南京中医药大学第一临床医学院,南京210029

出　　处：《神经解剖学杂志》2001年第2期183-186,共4页Chinese Journal of Neuroanatomy

基　　金：国家自然科学基金 (No.3 96 70 896 )资助项目

摘　　要：本研究在成功建立幼龄厌食大鼠模型的基础上 ,用运脾复方灌胃 3周 ,采用细胞外记录法 ,记录实验动物摄食中枢和饱中枢神经元的单位放电频率 ,并在对照组、模型组和运脾组之间进行对比 ,以观察运脾复方对幼龄厌食大鼠摄食中枢和饱中枢神经元自发放电的影响 ,藉以探讨运脾复方治疗小儿厌食症的作用机制。结果表明 :模型动物摄食中枢神经元放电频率显著降低(P<0 .0 5 ) ;运脾组摄食中枢神经元放电频率增高 (P<0 .0 5 ) ,同时饱中枢神经元放电频率降低 (P<0 .0 5 )。本实验提示 ,运脾复方能抑制模型动物饱中枢放电 ,刺激摄食中枢放电 ,通过调整摄食中枢和饱中枢电活动之间的相互关系 ,可使模型动物摄食量增加。After making the juvenile rat model with anorexia successfully, using the extracellular recording method, we recorded the frequencies of spontaneous discharge of neurons in LH and VMH of the model and studied the effects of Yunpi Fufang on the discharges of model group in order to explore the mechanism of Yunpi Fufang on anorexia for children. The results indicated that the discharges of neurons in LH of the model were suppressed, and Yunpi Fufang could enhance the discharges in LH, while inhibit the discharges in VMH. These findings suggest that Yunpi Fufang can modulate the relation of discharges between LH and VMH and then increase the feeding of the model.

关 键 词：运脾复方 自发放电 摄食中枢 饱中枢 动物模型 小儿厌食 大鼠 下丘脑 

分 类 号：R285.5[医药卫生—中药学]