大鼠多囊卵巢颗粒细胞凋亡时MDA含量及SOD活性的变化  

THE CHANGE OF MALONDIALDEHYDE AND SUPEROXIDE DISMUTASE IN APOPTOTIC GRANULOSA CELL OF RAT PCO

作　　者：朱辉[1] 倪江[1] 张玮[1] 李庆雷[1] 

机构地区：[1]哈尔滨医科大学生理教研室生殖内分泌研究室,黑龙江哈尔滨150086

出　　处：《中国应用生理学杂志》2001年第3期293-295,共3页Chinese Journal of Applied Physiology

摘　　要：目的和方法 :以大鼠多囊卵巢 (PCO)为动物模型 ,观察了PCO大鼠卵泡颗粒细胞凋亡的发生率 ,并检测了颗粒细胞凋亡时丙二醛 (MDA)的含量及超氧化物歧化酶 (SOD)活性的变化。结果 :①PCO颗粒细胞凋亡发生率明显高于正常 (P <0 .0 0 1) ;②PCO颗粒细胞发生凋亡时 ,细胞内MDA含量增加而SOD活性降低。结论Aim and Methods: Rat PCO model was established according to the method of Bogovich.Granulosa cells were collected for apoptotic analysis by Tunel method and for mesurement of MDA and SOD.Results:①The percentage of apoptotic granulosa cells of rat PCO was higher than control group( P <0.00l ).②Higher MDA and lower SOD were detected in granulosa cells of rat PCO.Conclusion:The change of MDA and SOD are associated with granulosa cell apoptosis in rat PCO.

关 键 词：多囊卵巢 颗粒细胞凋亡 丙二醛 超氧化物歧化酶 

分 类 号：R711.75[医药卫生—妇产科学]