肌成纤维细胞与血管重塑  

Myofibroblasts and vascular remodeling

作　　者：高平进[1] 朱鼎良[1] 

机构地区：[1]上海第二医科大学瑞金医院,上海市高血压研究所上海200025

出　　处：《北京大学学报（医学版）》2001年第4期313-315,共3页Journal of Peking University:Health Sciences

基　　金：国家重点基础研究发展规划项目基金 (973)基金 (G2 0 0 0 0 5 6 90 4)资助&&

摘　　要：Recent findings demonstrate that adventitial fibroblasts are endowed with several characteristics previously attributed to medial smooth muscle cells. Rapid activation of adventitial fibroblast, which proliferate, migrate, and undergo differentiation to myofibroblasts after balloon induced coronary injury. Myofibroblasts are involved in remodeling of adventitia and may contribute to the formation of the neointima. This review will illustrate the morphologic features, phenotypic modulation of myofibroblasts and its role in vascular remodeling, which raises the possibility of targeted therapies.Recent findings demonstrate that adventitial fibroblasts are endowed with several characteristics previously attributed to medial smooth muscle cells. Rapid activation of adventitial fibroblast, which proliferate, migrate, and undergo differentiation to myofibroblasts after balloon induced coronary injury. Myofibroblasts are involved in remodeling of adventitia and may contribute to the formation of the neointima. This review will illustrate the morphologic features, phenotypic modulation of myofibroblasts and its role in vascular remodeling, which raises the possibility of targeted therapies.

关 键 词：成纤维细胞 肌成纤维细胞 血管重塑 血管损伤 

分 类 号：R543[医药卫生—心血管疾病] R541[医药卫生—内科学]