肌红蛋白、肌钙蛋白T、肌酸激酶同工酶的检测对老年急性心肌梗死溶栓再通的判定价值  

Values of serum myoglobin,troponin T and creatine kinase MB in assessing reperfusion after thrombolysis for the aging acute myocardial infarction

作　　者：孙津红[1] 刘铭[1] 徐仰红[2] 田建立[1] 冯淑芝[1] 肖广辉[1] 孙雯[1] 

机构地区：[1]天津医科大学总医院老年病研究室,300052 [2]天津医科大学总医院老年病心脏科,300052

出　　处：《临床内科杂志》2001年第5期357-359,共3页Journal of Clinical Internal Medicine

摘　　要：目的　探讨血清肌红蛋白 (Mb)、肌钙蛋白T(cTnT)和肌酸激酶同工酶 (CK MB)对老年急性心肌梗死溶栓疗效的早期判定价值。方法　应用酶联免疫分析法测定 32例老年急性心肌梗死患者溶栓治疗后的Mb、cTnT、CK MB浓度 ,分析急性心肌梗死患者溶栓再通组 ( 1 8例 )和溶栓未通组 ( 1 4例 )上述指标的变化。结果　急性心肌梗死溶栓再通组Mb、cTnT和CK MB达到峰值浓度的时间明显较未通组提前 ( P <0 .0 5) ,其中Mb较cTnT和CK MB峰值出现更早 ,分别为( 7.4± 2 .5)h、( 1 3.7± 4.1 )h和 ( 1 4.4± 2 .7)h (P <0 .0 1 ) ;Mb的诊断敏感性 ( 79% )与诊断效率( 87% )明显高于cTnT( 6 0 %、75% )和CK MB( 47%、6 7% ) (P <0 .0 1 )。结论　血清Mb、cTnT和CK MB水平及其变化可以较好地早期预测急性心肌梗死患者溶栓再通 ,其中Mb较cTnT及CK MB具有更好的的临床价值。Objective To investigate and compare the clinical usefulness of serum myoglobin(Mb) , troponin T(cTnT), and creatine kinase MB(CK MB) mass in the early detection of reperfusion after thrombolytic treatment in aging patienst. Methods Blood samples taken from 34 patients with acute myocardial infarction were tested by ELISA method. Concentrations of Mb, cTnT, and CK MB were assayed in each sample. Thrombolytic treatment was given to the patients who were divided into those who reperfused(n=18) and those who failed to reperfuse (n=14).Results The time to reach peak value of Mb, cTnT, and CK MB were earlier in the patients who reperfused than those of patients who unreperfused, and Mb is more early than cTnT and CK MB. The sensitivity and diagnosis efficiency of Mb were higher than those of cTnT and CK MB. Conclution Myoglobin has greater potential than cTnT and CK MB examined in the detection of reperfusion after thrombolytic treatment in aging.

关 键 词：急性心肌梗死 溶栓疗法 肌红蛋白 肌钙蛋白T 肌酸激酶同工酶 

分 类 号：R542.22[医药卫生—心血管疾病]