毛细管电泳法测定泛昔洛韦的含量  

Determination of famciclovir by capillary electrophoresis

作　　者：金瓯[1] 黄宗玉[1] 

机构地区：[1]浙江省药品检验所,浙江杭州310004

出　　处：《中国生化药物杂志》2001年第4期189-190,共2页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的研究毛细管电泳法测定泛昔洛韦的含量。方法用 5 0mmol/L磷酸盐缓冲液 (pH 3 .0 ) ,毛细管柱(75 μm× 5 0cm) ,以托吡卡胺为内标于 2 10nm波长处测定泛昔洛韦的含量。 结果泛昔洛韦在 0 .0 5～ 0 .5mg/ml浓度范围内与泛昔洛韦和内标峰面积之比呈良好线性关系 ,回收率为 99.5 3 % ,RSD为 0 .9% (n =10 )。结论此法结果准确 ,重现性好 。PurposeThe aim is to determine famciclovir by capillary electrophoresis.MethodsPhosphate buffer(50 mmol/L pH 3.0) and tropicamide was used as internal standard to determine famciclovir at 210 nm.50 cm×75 μm uncoated capillary was used.ResultsGood linearity was obtained between Famciclovir and the ratio of Famciclovir and internal standard peak area and concentration ranges from 0.05～0.5mg/ml.The average recoveries( n =10) were 99.53%, RSD was 0.9%.ConclusionThis method was accurate and well reprodu cible,so it was suitable for quality control.

关 键 词：泛昔洛韦 毛细管电泳 含量 测定 抗病毒药 

分 类 号：R927.2[医药卫生—药学] R978.7