降钙素基因相关肽对高血压性与运动性心肌肥厚影响的对比研究  

CONTRAST STUDY OF CALCITONIN GENE RELATED PEPTIDE INFLUENCING THE HYPERTENSIVE AND EXERCISED MYOCARDIAL HYPERTROPHY

作　　者：李春跃[1] 韩补生[1] 南瑞生[1] 

机构地区：[1]内蒙古医学院生理教研室,内蒙古呼和浩特010059

出　　处：《内蒙古医学院学报》2001年第2期79-81,共3页Acta Academiae Medicinae Neimongol

基　　金：内蒙古自然科学基金资助项目 号 :980 91

摘　　要：目的 :探讨高血压性与运动性心肌肥厚的产生机制的差异。方法 :以缩窄大鼠的腹主动脉加盐负荷制作高血压性心肌肥厚 ,以游泳运动制作运动性心肌肥厚模型 ,用特异性放射免疫测定技术 ,检测心肌组织和血浆中降钙素基因相关肽 (CGRP)的含量。结果 :高血压组大鼠心肌组织和血浆中CGRP含量显著低于运动组和对照组 (P <0 0 5 )。结论 :CGRP可能在降低心肌肥厚程度中具有一定作用 ,并有利于肥厚心肌血液供应 ,使心肌收缩功能增强。Objective:To investigate the differences in developing mechanism between hypertensive myocardial hypertrophy and exercised myocardial hypertrophy. Methods:The model of hypertensive myocardial hypertrophy was made by constricting abdominal aorta of rats and feeding salt, and exercised myocardial hypertrophy by swimming exercises. Specific radioimmunoassay was applied to test the content of CGRP in myocardium and plasma. Results:The content of CGRP in both myocardium and plasma in hypertensive group is significantly lower than tnat in exercise group and control group (P<0 05). Conclusion:CGRP has relation to the development of myocardial hypertrophy. CGRP can reduce hypertrophy degree of myocardium, and improve blood supply of hypertrophic myocardium and enhance contracting function of myocardium.

关 键 词：心肌肥厚 高血压 运动 降钙素基因相关肽 

分 类 号：R544.1[医药卫生—心血管疾病]