双-对二甲氨基苯甲醛缩二胺类希夫碱合成、表征及抗菌活性  

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF BIS-p-DIMETHYLAMINOBENZALDEHYDE-SEMIDIAMINE SCHIFF BASES

作　　者：杨树平[1] 高乌恩[1] 杨丽敏[2] 吴冬梅[1] 嘎鲁[1] 

机构地区：[1]内蒙古医学院药学系药物化学教研室 [2]内蒙古医学院基础部微生物教研室,内蒙古呼和浩特010059

出　　处：《内蒙古医学院学报》2001年第2期101-103,共3页Acta Academiae Medicinae Neimongol

摘　　要：目的 :合成双 -对二甲氨基苯甲醛缩二胺类希夫碱 ,并对其抗菌活性进行研究。方法 :以对二甲氨基苯甲醛和二胺类为原料 ,经缩合反应 ,制得 4种相应希夫碱。结果 :结构经元素分析、红外光谱、核磁共振谱确定 ,4种化合物均未见文献报道 ,抗菌活性测试表明 ,它们具有一定抗菌活性。结论 :乙酸是催化剂 ,对缩合反应有利 ,希夫碱化合物具有一定抗菌活性。Objective:Four novel bis-p-dimethylaminobenzaldehyde-semidiamines Schiff bases were synthesized and screened for antibacterial activity. Methods:Four Schiff bases were prepared from p-dimethy laminobenzaldehyde and diamines by condensation reaction. Results:All the compounds were identified by elementary analysis、 IR and H 1NMR. Pharmacological tests showed that all of them had antibacterial activities. Conclusion:Acetic acid is an important catalyst in the condensation reaction. Schiff bases had antibacterial activity.

关 键 词：希夫碱 二胺类 二甲氨基 苯甲醛 抗菌剂 合成 

分 类 号：TQ465.91[化学工程—制药化工] R979.1[医药卫生—药品]