海洛因成瘾者神经、内分泌及免疫系统超微病理变化研究  

Research of ultra-structural pathological changes of nervous,endocrine and immune system in heroin addicts

作　　者：李利华[1] 姚宏[1] 赵永和[1] 朱华[1] 邢豫明[2] 冯忠堂[3] 杨润祥[4] 

机构地区：[1]昆明医学院法医学系,云南650031 [2]云南省公安厅技术处,云南昆明650021 [3]昆明医学院神经科学研究所,云南650031 [4]云南省肿瘤医院综合内科,云南昆明650106

出　　处：《法医学杂志》2001年第3期145-147,共3页Journal of Forensic Medicine

基　　金：国家自然科学基金资助项目( No.39760076)

摘　　要：目的 研究海洛因成瘾者中枢神经、内分泌、免疫及生殖系统的超微结构变化。方法 应用透射电镜技术对 4例海洛因成瘾者中枢神经系统、内分泌系统、免疫系统以及生殖系统进行了观察。结果 神经系统表现为线粒体肿胀、嵴断裂、空泡变、内质网扩张、神经纤维数量减少、细胞器减少；免疫系统表现为淋巴细胞数量减少，胞浆成分减少，死亡细胞增多；内分泌系统表现为线粒体扩张，局部嵴断裂，内质网扩张；生殖系统表现为男性生精细胞减少，细胞器减少。女性未见卵泡结构。结论 海洛因滥用者的亚细胞超微结构呈急、慢性缺氧性变性、坏死改变。Objective To investigate ultrastructural pathological changes of Heroin－ Addicts.Methods Heroin－Addicts' central nervous system, endocrine system,immune system and reproductive system in 4 cases are observed by using transmission electron microscope(TEM).Results The changes of central nervous system are mitochondrion swelling, crista fragmentation and disappear. Endoplasmic reticulum dilation ,nervous fibres and cell organelles reduction ; mitochondrion swelling, Partial crista fragmentation and endoplasmic reticulum dilation are also found in endocrine system; Lymphocytes reduction, cytoplasm ingredient reduction and dead lymphocytes increase in immune system; in reproductive system, spermatogenic cells and cell organelles are reduced in the male and follicle disappeared in the female. Conclusion Ultra－ structural pathological changes of heroin－ addicts are presented acute, chronic oxygen deficiency degeneration and necrosis.

关 键 词：海洛因成瘾者 中枢神经系统 内分泌系统 免疫系统 生殖系统 超微病理变化 透射电镜技术 

分 类 号：R595.502[医药卫生—内科学]