普罗帕酮与洋地黄转复慢性心房颤动的比较  

A comparison between propafenone and digitalis in the therapeutic result of patients with chronic atrial fibrillation

作　　者：张增堂[1] 张永慧 

机构地区：[1]山东省莱芜市人民医院,271100 [2]山东省莱芜卫生学校

出　　处：《实用心脑肺血管病杂志》2001年第2期76-78,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的　比较普罗帕酮与洋地黄转复慢性房颤的作用。　方法　房颤发作时间大于 3周的患者随机分为普罗帕酮组和洋地黄组 ,普罗帕酮组先静脉推注普罗帕酮 2 mg/ kg,再以 5 m g/ kg维持 2 4小时 ,后改口服每天 45 0 mg治疗 4周。洋地黄组先静脉推注毛花甙 C0 .4m g,然后每 6小时静脉推注0 .2 m g,2 4小时后改口服地高辛每日 0 .2 5 m g。　结果　普罗帕酮组 17例 (48.6 % )转复为窦性心律 ,洋地黄组仅 2例转复成功。普罗帕酮组转复成功者与未转复者相比 ,左房内径明显较小 (P<0 .0 0 1) ,房颤持续时间显著较短 (P<0 .0 0 1)。　结论　普罗帕酮可有效地用于慢性房颤的转复 ,洋地黄转复慢性房颤疗效不佳 ;左房内径。Objective To compare the result between propafenone and digitalis for conversion of chronic atrial fibrillation. Methods Patients with an atrial fibrillation,Who continued more than 3 weeks,were randomly divided into propafenone group and digitalis group.In propafenone group the patients were given propafenone 2mg/kg intravenously first, at beginning,and 5mg/kg continued 24 hours,then 450mg/day,oral administration,for 4 weeks.Patients in digitalis group began with lanatoside C 0.4mg intravenously,followed every 6 hours and were given 0.2mg until 24 hours,then digoxin 0.25mg every day,for 4 weeks. Results Seventeen of 35(48.6%) patients with chronic atrial fibrillation converted to sinus rhythm in propafenone group,only two of 36(5.6%) patients converted to sinus rhythm in digitalis group.Patients who converted to sinus rhythm after treatment with propafenone,all had a shorter duration of atrial fibrillation and the atrial diameter was smaller too(P<0 001). Conclusion Propafenone can be used effectively for conversion of chronic atrial fibrillation to sinus rhythm,but then the left atrial diameter and duration of atrial fibrillation also obviously affect the success of conversion.

关 键 词：心房颤动 普罗帕酮 洋地黄 治疗 

分 类 号：R541.750.5[医药卫生—心血管疾病]