双环醇的抗病毒与肝细胞保护作用及其作用机制  

The anti-virus and hepatoprotective effect of bicyclol and its mechanism of action

作　　者：刘耕陶[1] 

机构地区：[1]中国医学科学院中国协和医科大学药物研究所,北京100050

出　　处：《中国新药杂志》2001年第5期325-327,共3页Chinese Journal of New Drugs

基　　金：国家科委 10 35工程项目! (94-ZD -0 2 )

摘　　要：双环醇是人工合成的一类抗慢性病毒性肝炎新药 ,具有显著的保肝作用和一定抗肝炎病毒活性。该药 5 0 ,10 0 ,2 0 0mg·kg-1ig对CCl4 、D 氨基半乳糖、对乙酰氨基酚引起的小鼠肝损伤以及卡介苗 +脂多糖 (LPS)诱导的小鼠免疫性肝炎均有明显降ALT和AST作用 ,并能减轻肝组织病理损伤。双环醇体外给药对 2 .2 .15细胞株分泌HBeAg和HBsAg有抑制作用 ,该药 0 .4和 0 .6 g·kg-1ig对鸭病毒性肝炎血清和肝脏的DHBV DNA有显著抑制作用 ,对该药作用的机制进行多方面研究的结果表明 ,双环醇不是转氨酶抑制剂 ,而是有清除自由基作用以保护细胞膜 。Bicyclol is a synthetic novel anti hepatitis drug.It has remarkable hepatoprotective and certain anti hepatitis virus actions.Oral administration of 50,100,200 mg·kg -1 bicyclol protected livers of mice from damage induced by CCl 4,D galactosamine,acetoaminophen and B.C.G.plus lipopolysacharides (LPS) expressed in decreases of ALT and AST as well as morphological damage of liver tissues.Addition of bicyclol to the cultivated 2.2.15 cell line inhibited secretion of HBeAg and HBsAg as well as HBV DNA level.The results of mechanistic study on bicyclol indicated that bicyclol is not an inhibitor of transaminase,but a cell membrane protector through elinmination of free radicals.Moreover,bicyclol can protect hepatocyte nuclear DNA from damage and reduce the apoptosis induced by immuno stimulating compound Con A. [

关 键 词：双环醇 肝损伤 肝炎病毒 药理学研究 

分 类 号：R978.7[医药卫生—药品] R969[医药卫生—药学]