司氟沙星注射液治疗急性细菌感染60例  

The efficacy of sparfloxacin in treatment of acute bacterial infections in 60 cases

作　　者：张晋琳[1] 祝彪[1] 王春森[1] 王小冬[1] 唐义平[1] 万纯黔[1] 甘茂周[1] 

机构地区：[1]四川省人民医院内科,成都610072

出　　处：《中国新药杂志》2001年第5期372-373,共2页Chinese Journal of New Drugs

摘　　要：目的 :观察国产司氟沙星注射液 (SPFX)治疗急性细菌感染的疗效和不良反应。方法 :共治疗 6 0例患者 ,随机分为试验、对照及开放组各 2 0例 ,试验及开放组静脉滴注SPFX 2 0 0mg·d-1,qd ;对照组静脉滴注氧氟沙星注射液 (OFX) 4 0 0mg·d-1,bid ;疗程均为 5～ 14d。结果 :试验及开放组共 40例 ,总有效率和细菌清除率为 95 %和93 .5 % ;对照组 2 0例 ,总有效率和细菌清除率为 80 %和 88.9%。用药中不良反应较轻 ,试验及开放组发生率 5 % ,对照组发生率 10 %。结论 :本药治疗临床常见的中重度急性细菌性感染疗效高 。Objective:To observe the efficacy and safety of domestic sparfloxacin (SPFX) parenteral solution in treatment of acute bacterial infections.Methods:60 patients were randomly and equally divided into SPFX,open and control group.The SPFX and open group both were treated with SPFX in once daily dose of 200 mg for 5～14 days.The control group was treated with ofloxacin (OFX) parenteral solution in twice daily dose of 400 mg for 5～14 days.Results:The total effective rate and bacterial clearance rate for 40 patients in the SPFX and open group were 95% and 93.5% respectively and those for the OFX group were 80% and 88.9% respectively.Conclusion:The domestic SPFX parenteral solution is effective in treatment of acute bacterial infections. [

关 键 词：司氟沙星 氧氟沙星 细菌感染 临床疗效 不良反应 

分 类 号：R978[医药卫生—药品] R969.4[医药卫生—药学]