中药提取物水苏糖对临床/亚临床肝性脑病的预防作用  

Prophylactic effect of stachyose extracted from a Chinese herb medicine on hepatic encephalopathy and subclinical hepatic encephalopathy in animal model

作　　者：李瑞军[1] 唐晓山[1] 杨昭徐[1] 

机构地区：[1]首都医科大学附属北京天坛医院消化内科,北京100050

出　　处：《中国新药杂志》2001年第6期428-430,共3页Chinese Journal of New Drugs

摘　　要：目的 :探讨中药提取物水苏糖对临床 /亚临床肝性脑病 (HE/SHE)的预防作用。方法 :乳果糖组、水苏糖组和葡萄糖对照组新西兰家兔各 8只 ,实验前行体感诱发电位 (SEP)、脑干听觉诱发电位 (BAEP)和动脉血氨检查。于 0 ,2 4h分别耳缘静脉注射硫代乙酰胺 (TAA) ,并在实验开始时 3组分别灌胃乳果糖、水苏糖和葡萄糖 (剂量均为 1.33g·kg-1)作为HE/SHE的预防性用药 ,待出现肝衰竭后重复检测SEP ,BAEP及动脉血氨。结果 :水苏糖组、乳果糖组家兔SEP ,BAEP各波潜伏期较对照组明显缩短 (P <0 .0 1) ,动脉血氨水平明显下降 (P <0 .0 1) ,水苏糖组和乳果糖组各波潜伏期和动脉血氨无差异 (P >0 .0 5 )。结论 :水苏糖对临床、亚临床肝性脑病有预防作用。Objective:To explore the effect of stachyose in prevention of HE (hepatic encephalopathy) and SHE (subclinical hepatic encephalopathy).Methods:24 New Zealand rabbits were equally divided into 3 groups.The SEP(somatosensory evoked potential),BAEP(brainstem auditory evoked potential),and artery blood ammonia were measured before initiation of the study.For prophylactic purpose,the animals in each group were treated intragastrically with 1.33g·kg -1 of lactulose,stachyose,or glucose respectively.Then,thioacetamide(TAA,a liver toxic agent) was administrated intravenously at 0 and 24h.The SEP,BAEP,and artery blood ammonia were remeasured until the occurance of hepatic failure.Results:In lactulose and stachyose groups,the latency was significantly shortened and the artery blood ammonia was significantly reduced in comparison with control.But no significant difference was observed between lactulose and stachyose groups.Conclusion:HE/SHE can be prevented by oral stachyose.

关 键 词：水苏糖 肝性脑病 乳果糖 亚临床肝性脑病 氨中毒 

分 类 号：R285.5[医药卫生—中药学] R575.2[医药卫生—中医学]