美发摩丝对小鼠免疫功能的抑制  

Suppressive effects of mousse(hair fixative) on immunological function of mice

作　　者：宋艳艳[1] 于素芳[2] 许洪芝[1] 张春玲[2] 王桂亭[1] 胡俊峰[2] 

机构地区：[1]山东医科大学公共卫生学院病毒学教研室,山东济南250012 [2]山东医科大学公共卫生学院劳动卫生教研室

出　　处：《中国工业医学杂志》2001年第3期146-147,共2页Chinese Journal of Industrial Medicine

基　　金：山东省卫生厅青年基金资助 (95CAICAA3)

摘　　要：目的　研究美发摩丝对小鼠免疫功能的影响。方法　选择体质量 18～ 2 2g的雌性昆明种小鼠 10只 /组 ,以美发摩丝 12 5mg/kg、2 5 0mg/kg、10 0 0mg/kg灌胃染毒 3周后进行体液免疫、细胞免疫、非特异性免疫及免疫脏器质量测试。结果　 2 5 0mg/kg、10 0 0mg/kg剂量组的胸腺和脾脏质量明显低于对照组 (P <0 0 1) ,PFC对数值、血清溶血素抗体积数、足跖肿胀度及碳廓清指数均低于对照组 (P <0 0 5 ,P <0 0 1)。Objective To study the effects of mousse (hair fixative) on the immunological function in mice.Methods 40 female Kunming mice(body weight 18～22g)were randomly divided into 4 groups,3 exposed groups were given mousse at the dose of 12 5mg/kg,250mg/kg or 1 000mg/kg per day by gastrogavage for 28d respectively;then the various the cellular,humoral and nonspecific immune indexes were examined.Results In 250mg/kg and 1 000mg/kg dose group,the thymus and spleen weight,the plaque forming cell count,the serum hemolysin volume,the toe thickness as well as the carbon clearance index were all significantly lower than those of control group(P<0 05,P<0 01).Conclusion Mousse has a notable suppressive effects on the immunological function of mice

关 键 词：摩丝 细胞免疫 体液免疫 非特异性免疫 抑制作用 

分 类 号：TQ658.32[化学工程—精细化工] R194.7[医药卫生—卫生事业管理]