谷氨酰胺对氟尿嘧啶引起大鼠小肠结构和色氨酸吸收功能改变的保护作用  

Protective effects of glutamine on small intestinal structure and tryptophan absorption in rats administrated with fluorouracil

作　　者：董红林[1] 杨晶[1] 吴定标[1] 徐刚[2] 

机构地区：[1]第一军医大学分校病理教研室,广州510315 [2]第一军医大学分校药理教研室,广州510315

出　　处：《基础医学与临床》2001年第4期374-377,共4页Basic and Clinical Medicine

摘　　要：为探讨谷氨酰胺对化疗大鼠小肠结构和吸收色氨酸功能的保护作用 ,通过胃管连续两天给予大鼠氟尿嘧啶12 5mg/ (kg·d) ,观察谷氨酰胺对氟尿嘧啶引起的大鼠肠道结构损伤、色氨酸吸收功能障碍及每日饮食量改变的影响。可见谷氨酰胺明显减轻氟尿嘧啶引起的大鼠小肠结构损伤、增加其每日饮食量和小肠对色氨酸的吸收、升高其动脉血谷氨酰胺浓度。To explore the protective effects of glutamine on small intestinal structure and tryptophan absorption in rats administrated with fluorouracil,the rats were given fluorouracil 125mg/(kg·d) by gavage for two days Observe the effects of glutamine in daily of diet, on the small intestinal structure,tryptophan absorption,and glutamine concentration of abdominal aorta Glutamine could significantly improve the healing of small intestinal structure injury and increase small intestinal tryptophan absorption, and aorta glutamine concentration in rats administrated with fluorouracil

关 键 词：肿瘤患者 化疗 小肠保护 谷氨酰胺 氟尿嘧啶 色氨酸 

分 类 号：R965[医药卫生—药理学]