M onte Carlo方法研究支气管组织自体荧光光谱  

AUTOFLUORESCENCE SPECTRUM OF HUMAN BRONCHIAL TISSUE BY MONTE CARLO MODELLING

作　　者：郑蔚[1] 黄志伟[1] 谢树森[1] 李涉洪[1] K rishnan S M Chia T C 

机构地区：[1]福建师范大学激光研究所,福州350007 [2]新加坡南洋理工大学生物医学工程研究中心 [3]新加坡南洋理工大学理学院

出　　处：《光子学报》2001年第6期669-674,共6页Acta Photonica Sinica

基　　金：国家自然科学基金资助项目 697780 2 9;福建省科委国际科技合作计划资助项目

摘　　要：在实验获得支气管组织显微荧光特性和有关光学特性参量的基础上 ,将支气管组织简化为三层光学模型 ,用 Monte Carlo方法模拟 44 2 nm He-Cd激光在组织模型中的光分布及自体荧光的逃逸函数 ,计算出各组织层对总体自体荧光的贡献 ,并模拟出逃逸到组织体表面的自体荧光光谱 .进一步实验测量与理论计算的自体荧光光谱比较表明 ,两者在 460～ 5 2 0 nm及60 0～ 70 0Based on tissue microscopic fluorescence properties and optical parameters,a three layer bronchial optical model was developed to calculate the excitation light (442nm) distribution in the tissue and the fluorescence escape function from the tissue by Monte Carlo simulations The contributions of each layer in the tissue to total autofluorescence signal observed at the tissue surface were also estimated Moreover,the fluorescence spectrum of the bronchial tissue was also modelled using the obtained tissue micro spectroscopic properties It is found that the theoretically modelled spectrum agrees well with the experimental in vitro tissue fluorescence in the spectral range between the 460～520nm and 600～700nm

关 键 词：荧光逃逸函数 激光诱导自体荧光 人 肺 支气管组织 蒙特卡罗模拟 

分 类 号：R329.435[医药卫生—人体解剖和组织胚胎学]