大骨节病儿童口服亚硒酸钠前后六趾骨的形态学观察  

Morphological Observation on Polydactylism of A Child with Kaschin-Beck Disease before and after Administration of Sodium Selenite

作　　者：张桂琴 刘锦先 王志武[1] 石玉霞[1] 李德安[1] 

机构地区：[1]哈尔滨医科大学大骨节病研究所

出　　处：《哈尔滨医科大学学报》1989年第3期207-210,234,共4页Journal of Harbin Medical University

摘　　要：本文首次报告了1例大骨节病儿童口服亚硒酸钠前后,六趾骨的形态学变化。患儿服硒7个月后未显示出硒对本例儿童软骨坏死有明显的修复作用。但对无明显坏变的软骨细胞改善了膜的稳定性,增强了膜性结构的功能。The paper first reported morphological changes including X-ray, pathology and ultrastructure in amputated Polydactylism of a child with Kaschin-Beck disease before and after administration of sodium selenite tablets. 7 months after administration, hair seleniumincreased from 48 ppb to 315 ppb, the X-ray lesion was not changed and chondronecrosis was still there Pathologically. It was demonstrated that there was no significant repairable effect of selenium on chonoronecrosis of Kaschin-Beck disease. But membranous stability of undegenerative chondrocytes was improved and function of membrane structrure was increased by electron microscopy. The results indicated that concave, sclerosis and widening of X-ray signs in the metaphysis meant significant chondronecrosis by study on the roentgenological changes compared with pathological changes.

关 键 词：大骨节病 亚硒酸钠 六趾骨 形态学 

分 类 号：R726.841[医药卫生—儿科]