血清α-谷胱甘肽-S-转移酶监测原位肝移植术后肝功能的初步研究  

Value of serum α-glutathione-S-transferase in monitoring of hepatic function after liver transplantation

作　　者：杨扬[1] 陈规划[1] 陆敏强[1] 赵继宗[1] 黄洁夫[1] 

机构地区：[1]中山医科大学附属第一医院器官移植科,广州市510080

出　　处：《中华肝胆外科杂志》2001年第8期469-471,共3页Chinese Journal of Hepatobiliary Surgery

基　　金：广东省科委重点攻关项目基金资助(9827815)

摘　　要：目的探讨血清α-谷胱甘肽-S-转移酶(α-GST)作为肝移植术后肝功能标志物的应用价值。方法 EIA 法动态监测14例肝移植受者血清α-GST、天门冬氨酸氨基转移酶(AST)和丙氨酸氨基转移酶(ALT)的活性变化。结果术后2周内未出现特殊并发症的10例受者血清α-GST、AST 和 ALT恢复正常水平的时间分别为2d、4d、5d。3例急性排斥受者血清α-GST 每日变化率显著高于 AST 和ALT,冲击治疗后血清α-GST 降至正常的时间比 AST 和 ALT 提前1～2d。结论血清α-GST 是肝移植术后肝功能变化的更敏感指标,优于传统的 AST 和 ALT 检测。Objective To explore the value of α-glutathione-S-transferase(α-GST)in monitoring of hep- atic function after liver transplantation.Methods The dynamic changes of serum α-GST,AST and ALT in 14 pa- tients after liver transplantation were monitored with enzymimmunoassay.Results In t0 patients without postoper- ative complications,α-GST,AST and ALT levels normalized in 2,4 and 5 days,respectively.In the other 3 pa- tients with acute rejection,there was significantly greater rate of median change per day in α-GST as compared with that in AST and ALT.α-GST level returned to the normal value 1 and 2 days prior to AST and ALT after successful treatment of acute rejection.Conclusions α-GST is a more sensitive marker of the hepatic function than conven- tional tests after liver transplantation.

关 键 词：肝移植 α-谷胱甘肽S-转移酶 肝功能 α-GST 

分 类 号：R657.3[医药卫生—外科学]