柳州市急性散发性病毒性肝炎的病原学和流行病学研究  

Pathogenic and Epidemiological Study on Acute and Sporadic Virose Hepatitis of Liuzhou City

作　　者：唐荣兰 韦福邦 朱万孚[2] 李奎[2] 庄辉 韦启援[3] 廖丹[3] 郭堑[3] 

机构地区：[1]广西柳州卫生学校,柳州市545006 [2]北京医科大学 [3]柳州市工人医院

出　　处：《中国公共卫生》2001年第9期831-832,共2页Chinese Journal of Public Health

摘　　要：目的　探讨柳州市急性散发性病毒性肝炎的分型构成及危险因素。方法　用酶联免疫法 (EIA)测柳州市 12 1例急性散发性病毒性肝炎血清的各型肝炎病毒急性期感染指标 ,用逆转录套式聚合酶链反应 (RT -nPCR)检测血清未能分型的18例血清的HEVRNA。结果　甲型、乙型、丙型分别占10 7%、5 8 6%、6 8% ,丙型与乙型同时感染占 0 8% ,戊型分别与甲型、乙型、丙型、庚型同时感染各 1例 ,共占 3 3 %。戊型 7例 ,血清学未能分型者检HEVRNA阳性 7例 ,则戊型肝炎共 14例占 11 6%。未分型占 9 1%。未检到单纯抗 -HGV阳性者。危险因素分析表明甲型肝炎的血液暴露史 ( 3 0 8% )高于乙型肝炎 ( 2 1 1% ) ,而乙型肝炎的肠道暴露史 ( 94 4 % )高于甲型肝炎 ( 92 3 % )。结论　该市急性散发性病毒性肝炎中乙型肝炎占比重最大 ( 5 8 7% ) ;血清学未能分型者HEV -RNA阳性较率高 ( 3 8 5 % ) ;甲型肝炎经血传染、乙型肝炎经消化道传染的方式有上升的趋势。Objective To investigate the formation of classified acute and sporadic viral hepatitis of Liuzhou city.Methods Acute-phase sera of 121 patients with acute sporadic virose hepatitis of Liuzhou city were detected for acute-phase markers of various hepatitis viruses by using an enzyme-linked immunoserbent assay(EIA).Eighteen patients' sera whose types couldn't be distinguished by serum were detected for HEV RNA by using a reverse transcription-nested plymerase chain reaction(RT-nPCR).Results Among the 121 patients with acute sporadic virose hepatitis,patients with HA,patients with HB and patients with HC were 10.7%,58.6% and 68.8%,respectively.Patients with HC and HB occuppied 0.8%,and HD patients,there was one patient who was simutaneously infected with HE respectively,the rate being 3.3%.There were 7 patients with hepatitis E.There were 7 positive patietns whose sera couldnot be classified among those who were detected for HEV RNA.There were 14 patients with hepatitis E all together,the rate being 11.6%,those whose sera couldnot be classified were 9.1%,pure anti-HGV positive patients were not detected.The analysis of risk factors showed that the exposure history of blood from patients with hepatitis A(30.8%) was higher than that of those with hepatitis B(21.1%) while intestines exposure history(94.3%) of patients with hepatitis B was higher than that of those with hepatitis A(92.3%).Conclusions Of acute virose hepatitises of Liuzhou city hepatitis B was the most(58.7%),HEV RNA positive patients were more(38.8%) among those whose sera couldn't be typed.There was a rising trend that hepatitis A was infected through blood and hepatitis B was infected through the alimentary canal.

关 键 词：急性散发性病毒性肝炎 病原学 流行病学 

分 类 号：R512.6[医药卫生—内科学] R183.4[医药卫生—临床医学]