补肾中药对肾阳虚大鼠垂体-睾丸超微结构的影响  

Effect of Kidney Tonify Herbs on Ultrastructure of Pituitary and Testis in Kidney Yang Deficiency Rats

作　　者：宋春风[1] 马洪骏[1] 吕佩源[2] 尹桂山[3] 

机构地区：[1]河北医科大学 [2]河北省人民医院神经内科 [3]河北医科大学中西医结合基础理论研究室

出　　处：《中医药研究》2001年第4期45-46,共2页Research of Traditional Chinese Medicine

摘　　要：目的 :探讨肾阳虚与下丘脑 -垂体 -睾丸轴功能的关系及补肾中药的调整作用。方法 :以醋酸可的松造成肾阳虚大鼠模型 ,取其垂体、睾丸进行透射电镜样品制备和观察。结果 :可的松致肾阳虚大鼠垂体促性腺激素分泌细胞内质网、高尔基体严重扩张 ,线粒体空化 ,细胞核固缩。睾丸曲细精管生精上皮细胞血睾屏障扩张 ,细胞中出现许多大小不等的空泡。补肾中药能够改善垂体超微结构的损伤 ,但却不能改变睾丸超微结构的损伤。结论Objective:To explore relationship of kidney yang deficiency and the function change of hypothalamus-pituitary-testis as well as the mechanism of kidney tonify herbs.Methods:The model of kidney yang deficiency were made by injecting acetic acid cortisone in rats.To observe the ultrastructure change of pituitary and testis in kidney yang deficiency rat and regulation of tonify kidney herbs for it by electron microscopy.Results:In gonadotroph of kidney yang deficiency rat which was injected cortisone,the endoplasmic reticulum and golgiosome expanded seriously,mitochondria cavitated and nucleus was pycnosis.The blood-testis barrier expanded and presented many different size vacuoles in seminiferous epithelium of testis convolutde seminiferors tubule.Kidney tonify herbs cadm improve the ultrastructure damage of pituitary of kidney yang decificency rat,but it can't modulate it of testis.Conclusions:Kidney yang tonify of kidney tonify herbs involved that it improve the ultrastructure damage of pituitary of kidney yang decificency rat.

关 键 词：肾阳虚 补肾中药 垂体 睾丸 超微结构 

分 类 号：R285.5[医药卫生—中药学]