颈椎病家兔颈椎间盘及血清中炎性生化介质的变化  

CHANGES OF INFLAMMATORY BIOCHEMICAL MEDIATORS FROM CERVICAL INTERVERTEBRAL DISC AND SERUM IN CERVICAL SPONDYLOSIS RABBITS

作　　者：贾其余 丁锷[1] 李保泉[2] 曹日隆[2] 

机构地区：[1]安徽省合肥市第二人民医院,安徽合肥230011 [2]安徽中医学院第一附属医院

出　　处：《安徽中医学院学报》2001年第4期46-47,共2页Journal of Anhui Traditional Chinese Medical College

摘　　要：目的 :观察颈椎病家兔炎性生化介质的变化。方法 :取出颈椎病家兔的颈椎间盘组织 ,匀浆 ,测定一氧化氮 (NO)、组胺、5 HT浓度 ;心脏采血测定血清NO浓度。结果 :与对照组比较 ,模型组颈椎间盘中NO、组胺、 5 HT水平显著升高 (P <0 .0 5或P <0 .0 1) ,血清中NO也显著升高(P <0 .0 5)。结论 :炎性生化介质在颈椎间盘退变和颈神经根病的病理机制中起着重要作用。Objective:To observe the changes of inflammatory biochemical agents in cervical spondylosis rabbits.Method:Cervical intervertebral discs were taken from cervical spondylosis rabbits.Nitric oxide(NO),histamine,5-hydroxytryptamine(5-HT)in homogenate were assayed.The blood samples were taken from the rabbit hearts for NO determination.Result:Compared with those of control group,the level of NO,histamine,5-HT in cervical intervertebral discs of model group significantly increased(P<0.05,or P<0.01).Serum NO concentration obviously increased also (P<0.05).Conclusion:Inflammatory biochemical mediators play an important role in cervical intervertebral disc degeneration and in the pathophsiology of cervical radiculopathy.

关 键 词：颈椎病 一氧化氮 组胺 5羟色胺 颈椎间盘 炎性生化介质 

分 类 号：R681.55[医药卫生—骨科学]