老年男性骨质疏松症患者骨密度和生化指标的变化  

The changes of bone mineral density and biochemical markers in male elderly patients with osteoporosis

作　　者：郭春英[1] 薛延[2] 董洁英[1] 李欣[1] 

机构地区：[1]北京积水潭医院干部科,100035 [2]北京积水潭医院生化研究室,100035

出　　处：《中华老年医学杂志》2001年第4期263-265,共3页Chinese Journal of Geriatrics

摘　　要：目的　了解老年男性骨质疏松症患者骨密度和骨代谢生化指标变化的特点。　方法　对 30例老年男性骨质疏松症患者进行腰椎 (L2 4 )骨密度 (BMD)、骨矿含量 (BMC)、血和尿骨代谢生化指标的测定 ,并与对照组进行比较。　结果　骨质疏松 (OP)组的BMD和BMC均显著小于对照组 ,分别比对照组下降 2 1 6 %和 2 5 % ;OP组骨形成指标血清碱性磷酸酶 (ALP)和C端骨钙素 (BGP)明显高于对照组 ,分别上升 2 5 4%和 2 2 2 % ;骨吸收指标尿羟脯氨酸与肌酐的比值 (HOP/Cr)和I型胶原N 末端肽与肌肝的比值 (INTX/Cr)明显高于对照组 ,分别上升 2 2 6 %和 2 2 3 %。OP组血清T水平明显低于对照组 ,两组血清 2 5 羟维生素D3(2 5 OH D3)均在正常低限或低于正常水平。　结论　腰椎 (L2～ 4 )BMD和BMC是诊断男性骨质疏松症的主要依据 ;老年男性骨质疏松症患者一部分人属于骨代谢高转换型 ;雄激素对老年男性骨量的维持起重要作用 ;Objective To investgate the changes of bone mineral density (BMD) and biochemical markers of bone metabolism in elderly male patients with osteoporosis (OP) . Methods BMD and bone mineral content (BMC) of the lumbar spines (L 2～4 ) and the biochemical markers of bone metabolism in serum and urine were measured. Results BMD and BMC in OP group was reduced by 21.6% and 25% respectively vs that in control group. Bone formation indicators of serum levels of ALP and BGP in OP group were increased by 25.4% and 222% respectively vs that in control. At the same time, bone resorption indicators of urine Hop/Cr and NTX/Cr ratios were significantly increased by 22.6% and 223% in OP group than that in control. Serum T level of OP group was lower than that in control group and serum 25 OH D3 was below the normal value in both groups. Conclusions BMD and BMC of the lumbar spines (L 2 4 ) are the main basis for diagnosing the osteoporosis in men. Some elder male patients with osteoporosis are due to high turnover of bone metabolism. Androgen plays an important part in maintaining the bone mass. Vitamin D deficiency in elder men is the main reason occurring osteoporosis.

关 键 词：骨质疏松 骨密度 生化指标 老年人 男性 

分 类 号：R58[医药卫生—内分泌]