子宫内膜增生性病变中Bcl-2、ER、PR表达及相关性研究  

Study on Expression and Correlation of Bcl-2, ER and PR in Endometrial Hyperplasia

作　　者：韩玉崑[1] 刘丽[1] 苏菊[1] 

机构地区：[1]天津医科大学总医院妇产科,300052

出　　处：《天津医药》2001年第9期523-525,共3页Tianjin Medical Journal

摘　　要：目的:了解绝经过渡期功血患者子宫内膜病理学改变与Bcl-2、雌激素受体(ER)、孕激素受体(PR)的相关性。方法:采用免疫组化法检测子宫内膜细胞的Bcl-2、ER、PR的表达。结果:增生性宫内膜Bcl-2、ER、PR水平与增生期之间无统计学差异,分泌期ER、PR水平低于增生性和增殖期(P<0.01),Bcl-2、ER、PR水平单纯增生>复合增生>不典型增生。结论:Bcl-2、ER、PR水平随着宫内膜的增生程度下降,以此监测病变的不良倾向有重要的临床意义。To study the expression and correlation of Bcl-2, ER and PR in endometrial hyperplasia in perimenopausal women. Methods: The expressions of Bcl-2, ER and PR in endometrial cells were detected with an immunohistochemical method. Results: There were no significantly statistical differences of Bcl-2, ER and PR levels between endometrial hyperplasia and proliferative phase endometrium. The levels of Bcl-2, ER and PR in simple hyperplasia were higher than those in complex hyperplasia, and were lowest in atypical hyperplasia (P<0.01). Conclusion: When the degree of endometrial hyperplasia elevates, the levels of Bcl-2, ER and PR decline. It is an important indicator for monitoring pathologic changes.

关 键 词：子宫内膜增生 雌激素受体 孕酮受体 BCL-2 子宫出血 

分 类 号：R711.52[医药卫生—妇产科学]