骨折端注射“促骨愈合素”对骨愈合影响的实验研究与临床应用  

DIRECT INJECTION OF DRUG TO. FRACTURE SITE TO PROMOTE HEALING:AN EXPERIMENTAL AND CLINICAL STUDY

作　　者：杨谦[1] 杨谦[1] 刘书华[1] 傅源[1] 刘旭明[2] 严新民 

机构地区：[1]兰州军区乌鲁木齐总医院创伤外科 [2]兰州军区乌鲁木齐总医院病理科 [3]兰州军区乌鲁木齐总医院制剂中心

出　　处：《解放军医学杂志》1991年第5期361-364,共4页Medical Journal of Chinese People's Liberation Army

摘　　要：家兔34只,双侧尺骨中段人工锯断,造成2mm骨缺损。左侧(药物侧)于术中当时及术后每隔3天注射“促骨愈合素”0.5ml,15天停药,右侧(对照侧)不注药。术后1～8周X线片及组织学检查结果表明,注药侧骨痂、骨小梁、钙盐等的出现及数量均明显优于对照侧。经两家医院协作治疗13例新鲜骨折和15例骨不连病人,结果满意。证实骨折端注射“促骨愈合素”能促进新鲜骨折愈合,缩短疗程,对骨不连可获完全治愈。In 14 rabits, the ulna of both forelimbs were sawed across, leaving a bone defect of 2 mm in each bone. On the left side, the drug was applied locally during the operative procedure, and it was injected to the fracture site q3d PO up to 15 days. The right side served as the control, and no drug was. used. Radiological and histologjcal examinations were performed in 1-8 week. The results show: the injected side is superior to the control side in the appearance and amount of callus and bone salt. 13 fresh fracture and 15 nonunion patients were treated in two hospitals was satisfactory result. The use of this drug of the fracture side was effective to promote the healing of fresh fracture, and treatment time can be shortened. Nonuion of bone can be cured. The mechanism lies in early maturation of chondrocyte, rapid absorption of hematoma and formation of ground substance.

关 键 词：骨折 骨不连 骨愈合 促骨愈合素 

分 类 号：R982[医药卫生—药品]