血清总胆汁酸测定在婴幼儿肝炎综合征中的应用  

Application of serum total bile acid determination in infantile hepatitis syndrome

作　　者：宋文琪[1] 张美和[1] 王艳[1] 周敏[1] 曾俊红[1] 

机构地区：[1]北京儿童医院检验科,100045

出　　处：《中华检验医学杂志》2001年第4期227-229,共3页Chinese Journal of Laboratory Medicine

摘　　要：目的　通过检测血清总胆汁酸 (TBA)水平 ,确立该指标在婴幼儿肝炎综合征诊治中的意义。方法　采用全自动酶法分析技术对 6 7例婴幼儿肝炎综合征患儿 (年龄 2 6d～ 7个月 )及 10 0名正常对照组的婴幼儿 (年龄 2 0d～ 1岁 )进行空腹血清总胆汁酸测定 ,同时对其他肝功能相关项目进行测定。结果　正常对照组TBA值频数呈正偏态分布 ,经对数转换后 ,正态性D检验呈对数正态分布参考范围 :0～ 11.3μmol/L。患儿组测试结果 :TBA异常率达 89.5 % ,数值范围 :0 .5～ 2 2 6 μmol/L[ x±s =(79.5± 5 4.3) μmol/L],与正常对照组差异有显著意义。患儿组TBA与血清碱性磷酸酶(ALP)、直接胆红素 (DBIL)、及γ 谷氨酰转移酶 (γ GT)的检测水平有良好的相关性。且TBA在灵敏度和特异性上均优于以往的指标。结论　血清TBA的测定在婴幼儿肝炎综合征的诊断。Objectives To determine the significance of serum total bile acid (TBA) in the diagnosis and treatment of infantile hepatitis syndrome. Methods Serum TBA and other liver function related items were determined with automatic enzymatic assay techniques in 67 with infantile hepatitis syndrome patients (age 26 days～7 months) and 100 normal infants (age 20 days～1 year). Results In the control group, the serum TAB level was 0～11.3 μmol/L. TBA level was abnormal in 89.5% patients and the values were 0.5～226.0 μmol/L ±s =(79 5±54.3) μmol/L]. The difference was significant between the two groups. The TBA levels were well related to those of ALP, DBIL and γ GT and TBA was better than others in sensitivity and specificity. . The difference was significant between the two groups. The TBA levels were well related to those of ALP, DBIL and γ GT and TBA was better than others in sensitivity and specificity. Conclusion Serum TBA level is important in evaluating the diagnosis, treatment, and prognosis of infantile hepatitis syndrome.

关 键 词：胆汁酸 酶法分析 血清 婴幼儿 肝类综合症 TBA 

分 类 号：R446.1[医药卫生—诊断学]