苯酚化学剥脱术后雀斑皮肤组织的病理变化  

Histopathological changes of skin in freckle patients after phenol chemical peel

作　　者：赵启明[1] 陈志勇[1] 张承驹[1] 黄晓峰[2] 王圣林[1] 夏东胜[1] 吴律文[1] 

机构地区：[1]杭州市解放军117医院美容整形科,310013 [2]第四军医大学电镜中心

出　　处：《中华医学美学美容杂志》2001年第3期120-123,共4页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的　研究苯酚化学剥脱术后皮肤组织的病理变化。方法　苯酚化学剥脱术后 ,用免疫组化ABC法染色及透射电镜 ,对 15例雀斑患者皮肤进行了观察。结果　苯酚化学剥脱术后 ,表皮基底层的黑色素颗粒数量明显减少 ,真皮层弹力纤维和胶原纤维明显增粗、增多 ,皮肤增厚。结论　雀斑化学剥脱术后 ,表皮层细胞黑色素颗粒数量明显减少 ,雀斑消失 ;真皮层成纤维细胞增殖活性提高 ,引起弹力纤维和胶原纤维增粗、增多 。Objective To study the histopathological changes of skin after phenol chemical peeling.Methods Immunohistochemical staining (ABC method) and transmission electron microscopy were used to investigate the skin of changes 15 cases of freckle.Results After phenol chemical peeling,the melansomes in basal layer cells decreased dramatically, the elastic and collagenous fibers in dermis enlarged ,and the skin thickened .Conclusions After phenol chemical peeling,the melansomes in cuticular layer cells decrease remarkably and the freckle disappears.The proliferative activitities of fibroblasts in dermis have been improved,resulting in thickness of elastic and collagenous fibers in dermis. It may be the reason why the skin delays to be aged.

关 键 词：雀斑 苯酚 化学剥脱术 皮肤组织 病理变化 

分 类 号：R758.43[医药卫生—皮肤病学与性病学]