皮肤溃疡边缘血管内皮生长因子表达的研究  

Overexpression of vascular endothelial growth factor in epidermis of human skin ulcerous margin

作　　者：孙令[1] 赵晔[1] 王傲雪[1] 巴东霞[1] 贺迎霞 

机构地区：[1]大连医科大学附属二院皮肤科,116027 [2]辽宁油田中心医院皮肤科

出　　处：《中华医学美学美容杂志》2001年第3期124-126,共3页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的　观察外伤性皮肤溃疡表皮血管内皮生长因子 (VEGF)的表达。方法　应用免疫组织化学染色方法 ,用抗VEGF抗体及CD34抗体染色 6例皮肤溃疡患者的溃疡活检标本。结果　正常人表皮VEGF基本无染色 ;将整个皮肤溃疡标本分为正常部、周边部、边缘部及中心部 :正常部无染色 ;周边部表皮上层VEGF明显染色 ;溃疡组织边缘部在表皮下层明显表达VEGF ;溃疡组织中心部表皮无染色。CD34染色显示真皮毛细血管增生 ,管腔扩张 ,以周边部和边缘部真皮毛细血管增多显著。结论　外伤性皮肤溃疡表皮分泌VEGF ,促进血管新生和管腔扩张 ,对溃疡的愈合产生一定作用。Objective To investigate the expression of vascular endothelial growth factor(VEGF) in human skin ulcer margin. Methods Ulcer biopsy samples were stained with anti VEGF and CD34 antibodies by immunohistochemistry .Results VEGF was not expressed in normal epidermis. The ulcer specimen was divided into normal,peripheral,marginal and central parts. Epidermis of normal part was not stained. VEGF was obviously expressed in peripheral upper epidermis of ulcer and lower epidermis of ulcer margin. Central part was not stained due to shedding of epidermis. And also CD34 staining demonstrated that dermal capillaries increased obviously and lumen dilated, which was marked in the periphery and the margin of ulcer. Conclusions VEGF is secreted in skin ulcerous epidermis and promotes angiogenesis and vascular dilataion which play a role in ulcer healing.

关 键 词：皮肤 溃疡 血管内皮生长因子 VEGF 皮肤美容 

分 类 号：R632.1[医药卫生—外科学]