绞股蓝在大鼠肝的抗脂质过氧化作用  

Inhibitory effects of gynostemma pentaphyllum on lipid peroxidation reaction in rats liver

作　　者：陶建武[1] 姚彩萍[1] 王冀春[1] 郝广丽[1] 叶正君[1] 

机构地区：[1]湖北药检高等专科学校实验中心,武汉430064

出　　处：《中国临床药学杂志》2001年第3期160-162,共3页Chinese Journal of Clinical Pharmacy

摘　　要：目的 :观察绞股蓝 (GP)对四氯化碳 (CCl4)所致肝脏脂质过氧化的干预作用。方法 :将 Wistar大鼠随机分为 4组 :A(对照组 ) ;B(CCL4) ;C(GP) ;D(CCL4+ GP)。结果 :CCL4组的脂质过氧化物 (L PO )含量明显高于对照组 ,谷胱甘肽过氧化物酶 (GSH- Px)活性低于对照组 ;而同时给予 GP的 D组可减弱 CCL4诱发的上述作用。结论 :GP能减弱AIM: To observe inhibitory effects of gynostemma pentaphyllum (GP) on liver lipid peroxidation caused by carbon tetrachloride (CCl 4). METHODS: Wistar rats were randomly divided into 4 groups: A (control); B (CCl 4); C (GP); D (CCl 4+GP). RESULTS: The content of lipid peroxide (LPO) increased and the vitality of glutathione peroxidase (GSH Px) decreased in CCl 4 group compared with the control group. The lipid peroxidation caused by CCl 4 was inhibited by administering GP simultaneously. CONCLUSION: The results indicate that GP could decrease liver injury induced by CCl 4.

关 键 词：绞股蓝 脂质过氧化物 谷胱甘肽过氧化物酶 药理学 GP 

分 类 号：R965[医药卫生—药理学]