蒿甲醚预防耕牛血吸虫病的研究  

STUDIES ON PREVENTIVE EFFECT OF ARTEMETHER AGAINST SCHISTOSOMIASIS IN CATTLE

作　　者：葛继华[1] 汪天平[1] 吕大兵[1] 张世清[1] 张功华[1] 肖祥[1] 姚慈祥 潘新平[3] 

机构地区：[1]安徽省血吸虫病防治研究所,芜湖241000 [2]安徽省铜陵县畜牧兽医站 [3]安徽省铜陵县血吸虫病防治站

出　　处：《中国血吸虫病防治杂志》2001年第4期216-218,共3页Chinese Journal of Schistosomiasis Control

摘　　要：目的　观察耕牛口服蒿甲醚预防血吸虫感染的效果。方法　选择血吸虫病重流行区耕牛175头 ,按随机原则分为服蒿甲醚组和对照组 ,在感染季节前对所有受试对象用吡喹酮普治 ,实验组接触疫水后 15 d口服第 1剂蒿甲醚 4mg/kg,以后每 15 d服 1次 ,共 4次 ,对照组服安慰剂。两组牛群于末次服药后 1个月作粪检 ,考核预防效果。结果　实验组血吸虫感染率为 5 .41% ;对照组为16 .6 7% ,两者差异有显著意义 (χ2 =4.74,P<0 .0 5 )。实验组保护率为 6 7.5 5 % ,效果指数为 3.0 8。Objective To understand preventive effect of artemether against Schistosoma japonicum infection in cattle. Methods One hundred and seventy five cattle were chosen from a heavy schistosomiasis endemic village of lake and marshland type in Tongling County. The cattle were allocated randomly to artemether group and control (placebo) group. Praziquantel was given orally to all the cattle at routine dose before infection season. In artemether group, artemether was given to the cattle at first dose of 4 mg/kg 15 days after contacting with infested water, followed by repeated dose every 15 days for 3 times. In control group, time and dose of placebo was as the same as in artemether group. Stool examination was carried out 1 month after last administrating artemether or placebo for two groups so as to evaluate the preventive effect. Results Schistosome infection rates in artemether group and control group were 5 41%, 16 67% respectively. There was significant difference between infection rates in two groups(χ 2=4 74, P<0 05). Preventive rate amounted to 67 55%, effective index was 3 08 in artemether group Conclusion Cattle taking orally artemether during infective season can effectively prevent from Schistosoma japonicum infection.

关 键 词：蒿甲醚 日本血吸虫病 预防 耕牛 

分 类 号：S858.23[农业科学—临床兽医学] S852.735[农业科学—兽医学]