肝素钙与肾小球内基质金属蛋白酶表达的关系探讨  

Relation Between Hepacarin and the Expression of MMPs in Renal Glomerulus

作　　者：郑京[1] 王智[1] 滕云[1] 阮诗玮[1] 张洪生[1] 丘余良[1] 

机构地区：[1]福建中医学院附属人民医院肾科,350004

出　　处：《福建医药杂志》2001年第3期97-99,共3页Fujian Medical Journal

摘　　要：目的　探讨肝素钙在治疗增生性肾炎中的作用。方法　对 70例增生性肾小球肾炎患者 ,进行常规病理检查 ,并以免疫组化方法测定其肾小球基质金属蛋白酶 (MMPs)—— MMP- 2、 MMP- 3的表达。同时随机分为常规疗法(A组 )和常规疗法 +肝素钙 (B组 )两组。结果　 A组和 B组系膜增生程度、球性硬化、节段性硬化、 MMP- 2、 MMP-3表达无显著性差异。B组 10例血肌酐增高者治疗前后血肌酐和内生肌酐清除率有显著性差异。B组的疗效优于 A组。Objective To explore the therapeutic effects of hepacarin on proliferative nephritis Methods: 70 patients of proliferative nephritis were randomly divided into 2 groups:group A (receiving routine treatment)and group B(receiving hepacarin and routine treatment) All patients received renal biopsy The expressions of MMP 2 MMP 3 of renal glomerulus were determined by immunohistochemical method Results:There were no significant differences in the degree of mesangial proliferation and segmented sclerosis between two group.No different expressions of MMP 2 and MMP 3 were observed between A and B group The serum levels of creatinine of 10 patients in group B were higher than normal There were markedly different in Scr and Ccr between pre and post treatment of group B.The therapeutic effect of group B was superior to group A Conclusions: The therapeatic effect of hepacarin on the chronic nephritis was significant

关 键 词：慢性肾炎 病理分级 基质金属蛋白酶 肝素钙 

分 类 号：R692[医药卫生—泌尿科学]