重组修饰人肿瘤坏死因子突变体在小鼠体内的药代动力学(英文)  

Pharmacokinetics of recombinant modified human tumor necrosis factor mutant in mice

作　　者：蒋春雷[1] 李珍[2] 顾长虹 何成[1] 黄爱军[1] 袁伯俊 路长林[1] 

机构地区：[1]第二军医大学神经生物学教研室 [2]长海医院临床药理学研究室 [3]新药评价中心,上海200433

出　　处：《中国药理学与毒理学杂志》2001年第3期161-163,共3页Chinese Journal of Pharmacology and Toxicology

摘　　要：采用酶联免疫吸附测定法 ,检测血浆中新型重组人肿瘤坏死因子 (rhTNF NC)的含量 ,研究rhTNF NC在小鼠体内的药代动力学 .rhTNF NCiv后 ,血药浓度时间曲线符合非线性药代动力学特征 ,t1/2 β平均为 37.4min ,3个剂量的AUC分别为 4 .0 8,10 .3和57.3mg·min·L- 1,而Cls则分别为 0 .38,0 .18和0 .0 7mL·min- 1.Using sandwich enzyme linked immunosorbent assay, plasma levels of new recombinant modified human tumor necrosis factor mutant (rhTNF NC) were detected to examine the pharmacokinetics of iv rhTNF NC in mice. It was found that plasma concentration time curves after iv rhTNF NC in mice exhibited in a dose dependent manner. t 1/2β is 37.4 min. AUC of three different dosages are 4.08,10.3 and 57.3 mg·min·L -1 , and Cls are 0.38, 0.18 and 0.07 mL·min -1 , respectively.

关 键 词：肿瘤坏死因子 酶联免疫吸附测定 药代动力学 小鼠 血药浓度 

分 类 号：R965[医药卫生—药理学]