松树叶蜂性信息素中间体的合成研究  

Synthesis of the Intermediates of Sex Pheromone of Pine Sawfly

作　　者：孟 陈立功 古险峰 宋芸 张素峰 唐四华 

机构地区：天津大学药物科学与技术学院,

出　　处：《精细化工》2001年第6期358-359,共2页Fine Chemicals

基　　金：教育部高校骨干教师资助计划

摘　　要：3，7-二甲基-2-十三醇是松树叶蜂Diprion pini性信息素的前体化合物。设计并研究了一条新的3，7-二甲基-2-十三醇的合成路线，并对该路线中两个重要的中间体2-甲基-1-溴辛烷和3-甲基-4,4-［1′,2′-丙二氧基-2-戊酮进行了合成研究。丙二酸二乙酯经己基化、甲基化、水解、脱羧、还原、溴化得到2-甲基-1-溴辛烷，单程总收率为28.4%。2,4-戊二酮经甲基化、单羰基保护得到3-甲基-4,4-(1′,2′-丙二氧基)-2-戊酮，单程总收率为15.0%。Dimethyl 2 tridecanol is the precursor compound of the sex pheromone of pine sawtly (Diprion pini).A new route of synthesis for 3,7 dimethyl 2 tridecanol was studied in this paper,and the two important intermediates were synthesized.1 Bromo 2 methyloctane was obtained from diethyl malonate through hexylation,methylation,hydrolysis,decarboxylation,reduction and bromination,the overall yield being about 28 4%.3 Methyl 4,4 (1′2′ propylenedioxy) 2 pentanone was prepared from 2,4 pentanedione through methylation and carbonyl protection,the overall yield being about 15 0%.

关 键 词：松树叶蜂 性信息素 3 7-二甲基-2-十三醇 2-甲基-1-溴辛烷 3-甲基-4 4-(1′ 2′-丙二氧基)-2-戊酮 

分 类 号：TQ453.9[化学工程—农药化工] TQ224.4