P物质对大鼠离体卵巢孕酮和雌激素分泌的影响  

EFFECTS OF SUBSTANCE P ON THE SECRETION OF EXTRACORPOREAL OVARIAN PROGESTERONE AND ESTROGEN IN RATS

作　　者：姜恩魁[1] 焦金菊[1] 李金庆[1] 常志杰[1] 冯甲棣[2] 徐玉华 

机构地区：[1]锦州医学院生理教研室 [2]中国医学大学生理教研室 [3]锦州卫校生理教研室

出　　处：《锦州医学院学报》1991年第2期85-88,共4页Journal of Jinzhou Medical College

基　　金：本课题经费由国家计划生育委员会资助

摘　　要：本文应用组织培养技术和下丘脑—腺垂体—卵巢顺序灌注方法,研究了P 物质(SP)对雌性成年 Sprague—Dawley 大鼠离体卵巢孕酮和雌激素分泌的影响动物按阴道涂片分为动情期组和间情期组,并分别设立对照组。实验结果发现,实验组(于下丘脑培养液中加入 SP 5μg)自培养后等四天起孕酮和雌激素 F_2含量明显下降。提示 SP 对卵巢孕酮和雌激素生成有明显抑制作用。The methods of tissue eulture and sequence perfusion in hypothalamusn pituitary glands-Ovary were employed.The effects of substance p on the secretion of extracorpo real ovarian progesterone and estrogen were studied in adult Sprague-Dawley female rats,which had been divided into oestrus, diestrus groups according to the vaginal smear and the separate control groups. The experimental result showed that the contet of ovarian progesterone and estrogen of the experimental groups 5μg in the hypothalamic culture fluid) evidently decreased four days after the culture The.result of our studies sug- gested that substance p obviously inhibited the genesis of ovarian progesterone and estrogen.

关 键 词：P物质 卵巢 孕酮 雌激素 

分 类 号：R335.5[医药卫生—人体生理学]