红毛五加总苷对大鼠佐剂性关节炎的影响及其机制  

Effects of total glucosides of Acanthopanax giraldii on adjuvant arthritis in rats and its action mechanism

作　　者：骆勤[1] 党月兰[2] 李淑玉[2] 

机构地区：[1]兰州医学院附属第二医院药剂科,甘肃兰州730030 [2]兰州医学院药理教研室,甘肃兰州730000

出　　处：《中国药学杂志》2001年第6期385-388,共4页Chinese Pharmaceutical Journal

摘　　要：目的　研究红毛五加总苷 (TGA)对大鼠佐剂性关节炎的防治作用。方法　采用大鼠佐剂性关节炎模型进行观察。结果　TGA(2 0 0～ 80 0mg·kg-1,ig)能显著抑制大鼠佐剂性关节炎 (AA)致炎足和非致炎足的肿胀 ,使AA大鼠血清循环免疫复合物、MDA含量及小鼠血清溶血素和抗SRBC抗体凝集效价明显降低。结论　TGA对AA大鼠具有防治作用 ,其作用原理可能是抑制抗体形成。OBJECTIVE: To study the effects of total glucosides of Acanthopanax giraldii (TGA) on adjuvant arthritis (AA) in rats and the mechanism of its antiinflammatory action. METHODS: The model of AA was induced by injecting Freund's complete adjuvant (CFA) in rats. RESULTS: TGA (200 ∼ 800 mg kg-1, ig) significantly inhibited the injected and uninjected (Freund's) hind paw edema of AA rats. TGA also decreased the circulating immune complex (CIC) and MDA in serum of AA rats, and decreased the titer of hemagglutinin and hemolysin in mice. CONCLUSIONS: TGA possessed the prevention and therapeutic effects on AA rats.The mechanism of TGA antiinflammatory action probably is due to the inhibition of antibody and CIC formation, and the inhibition of lipid peroxidation.

关 键 词：佐剂性关节炎 经毛五加总苷 TGA 大鼠 影响 免疫复合物 抗体 

分 类 号：R684.3[医药卫生—骨科学] R967[医药卫生—外科学]