氯沙坦与吲哒帕胺联合治疗老年高血压病  

Efficacy and safety of losartan in combination with indapamide in the elderly with essential hypertension

作　　者：郑杭玲[1] 吴金彦[1] 

机构地区：[1]浙江医院心血管内科,浙江杭州310013

出　　处：《中国药学杂志》2001年第6期420-421,共2页Chinese Pharmaceutical Journal

摘　　要：目的　探讨联合应用氯沙坦和吲哒帕胺对老年轻、中、度高血压病的疗效、顺应性及对靶器官损害的影响。方法　采用自身对照方法 ,观察氯沙坦联合吲哒帕胺对 5 7例老年高血压患者动态血压及代谢参数的影响。氯沙坦剂量为 5 0mg/d ,吲哒帕胺为 2 .5mg/d ,疗程为 4个月。结果　总有效率为 89.5 % ,治疗后 2 4h收缩期均压、舒张期均压、白昼收缩期均压、夜间收缩期均压、夜间舒张期均压有非常显著降低 (P <0 .0 1) ,白昼舒张期均有显著降低 (P <0 .0 5 ) ;治疗后血肌酐、血 β2 微球蛋白、尿α1微球蛋白显著降低 (P <0 .0 5 )。结论　氯沙坦和小剂量吲哒帕胺联合应用 ,对老年轻、中、高度血压疗效显著 ,作用平稳 ,不影响代谢 。OBJECTIVE: To investigate the efficacy and safety of Losartan in combination with indapamide in elderly with essential hypertension. METHODS: 57 elderly patients with essential hypertension were treated with the combination of losartan and indapamide. 24 h ambulatory blood pressure monitoring and the metabolic parameters were observed. The total follow-up periods was 4 months. RESULTS: The total efficacy rate was 89.5%. There were significant reductions of 24 h MSBP,MDBP,dMSBP,nMSBP,nMDBP (P 1-MG were also significantly reduced (P < 0.05). CONCLUSIONS: The combination of losartan and indapamide for the treatment of essential hypertension in elderly was effective and safe.

关 键 词：氯沙坦 吲哒帕胺 高血压 老年人 药物联合治疗 

分 类 号：R544.1[医药卫生—心血管疾病]