黄芪对缺氧缺血性脑损伤幼鼠一氧化氮、丙二醛含量的影响  

Influences of Astragalus membranaceus(黄芪) on nitric oxide and malondialdehyde in young rats with hypoxicischemic brain damage

作　　者：裴林[1] 刘唤荣[2] 张少丹[3] 丁春华[2] 张建涛[1] 

机构地区：[1]河北省中医药研究院,河北石家庄050031 [2]河北医科大学 [3]河北省人民医院

出　　处：《中国中西医结合急救杂志》2001年第4期222-224,共3页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：河北省科研基金资助项目 ( No.992 76 2 17D子课题 )

摘　　要：目的 :观察黄芪对缺氧、缺血性脑损伤幼鼠脑组织一氧化氮 (NO)、丙二醛 (MDA )含量的影响。方法 :采用新生大鼠右侧颈总动脉结扎术 ,制备幼鼠缺氧、缺血性脑损伤模型。观察黄芪注射液对制模即刻及第 2、4日脑组织含水量、头部脑血流量、脑组织 NO和 MDA含量变化。结果 :模型组幼鼠脑组织含水量增加 ,脑血流量减少 ,NO、MDA含量增高 ;而应用黄芪注射液各组脑组织含水量降低 ,脑血流量明显增加 ,NO、MDA含量明显降低。结论 :黄芪具有消除幼鼠脑组织水肿 ,增加脑组织血流量 ,抑制脂质过氧化损伤 ,降低 NO及自由基损伤代谢产物 MDA含量的作用 ,对缺氧、缺血性脑损伤具有治疗作用。Objective:To investigate the influences of Astragalus membranaceus(黄芪) on nitric oxide (NO) and malondialdehyde (MDA) in the young rats with hypoxicischemic brain damage(HIBD).Methods:The young rat model with HIBD was built by ligating right carotid artery in newborn rat.The influences of Astragalus membranaceus injection(黄芪注射液) on cerebral tissue hydration,cerebral blood flow and NO and MDA in brain tissue were observed at present,on second day and fourth day.Results:In model group cerebral tissue hydration increased,cerebral blood flow decreased,the levels of NO and MDA increased.In Astragalus membranaceus injection group cerebral tissue hydration decreased,cerebral blood flow increased,the levels of NO and MDA decreased.Conclusions:Astragalus membranaceus has a protective effect on clearing cerebral edema,increasing cerebral blood flow,inhibiting the injury of lipid peroxidation,decreasing NO and MDA of the metabolic products of free radical injury.

关 键 词：黄芪注射液 缺氧缺血性脑损伤 一氧化氮 丙二醛 中医药疗法 

分 类 号：R285.5[医药卫生—中药学]