柔软肉芝软珊瑚中的新二萜内酯  

A New Diterpene Lactone from the Soft Coral Sarcophyton molle Tix. Dur.

作　　者：苏镜娱[1] 闫素君[1] 曾陇梅[1] 

机构地区：[1]中山大学化学系,广州510275

出　　处：《高等学校化学学报》2001年第9期1515-1517,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金 (批准号 :2 9772 0 5 8;2 992 0 30 );"九五"国家科技专项"南沙群岛及其邻近海区综合科学考察"项目(批准号 :97-92 6 -0 2 -0 3)资助

摘　　要：Two diterpene lactones, sarcophinone(1) and iso sarcophinone(2), which are biogenetically related to the sarcophine, were isolated from the soft coral Sarcophyton molle Tix. Dur. iso Sarcophinone 2 is a new compound. Its structure was determined to be C 1 epimer of sarcophinone by spectroscopic methods. Bioassay showed that both sarcophinone(1) and iso sarcophinone(2) had potent cytotoxicity toward Ehrlich and S180 tumor cell lines.Two diterpene lactones, sarcophinone(1) and iso sarcophinone(2), which are biogenetically related to the sarcophine, were isolated from the soft coral Sarcophyton molle Tix. Dur. iso Sarcophinone 2 is a new compound. Its structure was determined to be C 1 epimer of sarcophinone by spectroscopic methods. Bioassay showed that both sarcophinone(1) and iso sarcophinone(2) had potent cytotoxicity toward Ehrlich and S180 tumor cell lines.

关 键 词：软珊瑚 二萜内酯 结构测定 细胞毒性 生理活性 肿瘤细胞 抑制作用 

分 类 号：Q959.133[生物学—动物学] Q541