电针对血管性痴呆大鼠学习记忆行为及脑乙酰胆碱酯酶的影响  

Effects of Electroacupuncture on Learning and Memory Behaviour and Acetylcholinesterase of Brain in the rat of Vascular Dementia

作　　者：莫飞智[1] 李建强[2] 雷立屏[3] 陈朝晖[4] 赖新生[3] 

机构地区：[1]华南师范大学量子电子学研究所,广州市石牌510631 [2]广东省中医院 [3]广州中医药大学 [4]广州中医药大学第一附属医院实验中心

出　　处：《中医杂志》2001年第6期344-346,共3页Journal of Traditional Chinese Medicine

基　　金：广东省自然科学基金资助课题实验研究部分(960548)

摘　　要：为了探讨电针对血管性痴呆(VD)大鼠的疗效及乙酰胆碱酯酶(Acetyl—cholines terase,AChE)的影响,将大鼠制成肾性高血压(RHR)后再造脑反复缺血拟VD的大鼠30只,随机分为模型组、电针组和药物组(用氢化麦角碱,DHET)各10只,共治疗28天。治疗后均以水迷宫检测学习记忆行为情况,并检测脑AChE的含量。结果模型组水迷宫潜伏期明显长于电针组、药物组(P<0.05或P<0.01),药物组长于电针组(P<0.05或P<0.01)。在海马、纹状体,电针组和药物组的AChE含量显著高于模型组.而电针组又高于药物组(P<0.05),说明电针能改善VD大鼠学习记忆能力,提高脑AChE的含量并使之重新分布,其作用优于DHET。Effects of electroacupuncture (EA) on learning and memory and acetylcholinesterase (AChE) activity were investigsted in the rat of vascular dementia. Thirty rats were randomly divided into model group, EA group and medicine (Dyhydroergotoxine, DHET) group, 10 rats in each group. After treatment for 28 days, learning and memory behaviour were detected with water maze, and the AChE activity in brain was determined. Results showed that the latent period of water maze in the EA group and the medicine group was shorter than that of the model group (P < 0. 05 or P < 0. 01), respectively, and in the EA group was shorter than in the medicine group (P<0. 05 or P< 0. 01). The AChE activities of hippocampus and striatum in the EA group and the medicine group were higher than those in the model group, and the EA group was higher than the medicine group (P<0. 05). It indicates that electroacupuncture can promote the ability of learning and memory and enhance AChE activity of brain in rats of vascular dementia, and the therapeutic effect of electroacupuncture is better than that of DHET.

关 键 词：阿尔茨海默病 针灸治疗 乙酰胆碱酯酶 针灸效应 记忆 电针治疗 

分 类 号：R245.97[医药卫生—针灸推拿学]