兔脾动脉插管和耳静脉穿刺灌注氟尿嘧啶门静脉检测的药代动力学研究  

COMPARATIVE STUDY ON PHARMACOKINETICS OF 5-FU INJECTED VIA SPLENIC ARTERY AND AURICULAR VEIN IN RABBITS

作　　者：曾晓华[1] 王颂章[1] 吴笑春[1] 金德勤[1] 余爱荣[1] 郑湖民[1] 

机构地区：[1]广州军区武汉总医院,武汉430070

出　　处：《解放军医学杂志》2001年第7期512-513,共2页Medical Journal of Chinese People's Liberation Army

摘　　要：对比研究经脾动脉和耳静脉灌注氟尿嘧啶时经门静脉测定的药代动力学 ,以评价在肝恶性肿瘤的血管内介入治疗中 ,经脾动脉灌注化疗药的临床治疗价值。对脾动脉灌注组 (IA组 )和耳静脉灌注组 (IV组 )均行门静脉插管取样测定 ,采用高效液相色谱仪检测门静脉血中氟尿嘧啶 ,进行药代动力学对比分析。结果显示 ,IA组各血样的血药浓度均高于IV组 ,前者之血药峰值比后者高 6 4% ,前者曲线下面积比后者大 42 %。提示经脾动脉灌注化疗药 ,门静脉内可达较高血药浓度 。To study the pharmacokinetics of 5 FU after splenic artery(IA) and auricular vein(IV) infusion, portal vein blood was collected for measurement to appraise the clinical value of treatment with this anti tumor drug via different routes on malignant hepatic neoplasms. 5 FU in portal vein blood was measured with high performance liquid chromatography. The results showed that the concentration of 5 FU in IA group was higher than that in the IV group. The peak concentration of 5 FU in the IA group was higher than that in the IV group by 64%. The area under the curve (AUC) of 5 FU in the IA group was larger than that in the IV group by 42%. It suggested that higher concentration of anti tumor drug in the portal vein could be obtained via splenic artery infusion, and it is valuable for the treatment of malignant hepatic neoplasms.

关 键 词：氟尿嘧啶 药代动力 兔 脾动脉插管 耳静脉穿刺灌注 门静脉 

分 类 号：R979.1[医药卫生—药品] R969.1[医药卫生—药学]