非诺洛芬钙亲水凝胶缓释骨架片释药机理影响因素考察  

The study on the factors of the release mechanism of fenoprofen calcium from hydrophillic sustained-release matrix tablets

作　　者：赵春顺[1] 崔升淼[1] 郭晓蕾[1] 何仲贵[1] 张汝华[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2001年第4期239-243,共5页Journal of Shenyang Pharmaceutical University

摘　　要：研究了非诺洛芬钙亲水凝胶缓释骨架片释放机制的影响因素。通过对骨架材料的种类、型号及用量、填充剂的性质及用量、压片压力、制剂工艺等各因素对药物释放机制的影响考察发现 :骨架材料的种类及用量、填充剂的性质及用量和压片力对释药机制影响较大 ,其余因素影响较弱。The factors of the release mechanism of fenoprofen calcium (FC) from hydrophillic matrices were studied by evaluating the n value in the Peppas equation. The results indicated the release rate changed with the formulation. The sorts and content of hydrophillic polymer, the properties and content of filler excipient and the press of preparation affected the release mechanism of FC.

关 键 词：非诺洛芬钙 缓释骨架片 羟丙基甲基纤维素 释药机制 

分 类 号：R944.9[医药卫生—药剂学] R912[医药卫生—药学]