慢性肾功能不全患者血清Ⅳ型胶原和α_1-微球蛋白测定评价  

EVALUATION OF DETERMINATION OF SERUM IV-C AND α_1- MG OF THE PATIENTS WITH CHRONIC RENAL FAILURE

作　　者：万福俊 胥吉福 陆勇 李桂馥 张全[2] 高俊瑞[2] 

机构地区：[1]阜新矿务局总医院肾内科 [2]抚顺矿务局总医院肾内科

出　　处：《中国煤炭工业医学杂志》2001年第8期587-588,共2页Chinese Journal of Coal Industry Medicine

摘　　要：目的　为了探讨慢性肾功能不全患者血清Ⅳ型胶原 (typeⅣcollagen ,Ⅳ -C)和α1 -微球蛋白 (α1 -microglobulin ,α1 -MG)含量的变化和临床意义。方法　 76例慢性肾功能不全患者以血肌酐 (Cr)水平分为氮质血症组和尿毒症组 ,用放免分析法对全部患者血清Ⅳ -C和α1 -MG进行检测。结果　氮质血症组与尿毒症组血清Ⅳ -C和α1 -MG分别与正常对照组相比 ,相差均有显著性 (P<0 .0 5) ,尿毒症组血清α1 MG水平明显高于氮质血症组 (P <0 .0 1 ) ,尿毒症组与氮质血症组血清Ⅳ -C水平差异无显著性 (P >0 .0 5)。结论　血Ⅳ -C和α1 -MG测定可作为肾功能不全的实验室指标之一。Objective To investigate the clinical significance and alternation of serum type Ⅳ collagen (Ⅳ-C) andα 1-microglobulin (α 1-MG) levels of the patients with chronic renal failure. Methods 76 patients with chronic renal failure were divided into azotemia group and uremia group according to their serum creatitine (Cr), and the patients' serum Ⅳ-C and α 1-MG levels were determined by radioimmunoassary. Results Serum Ⅳ-C and α 1-MG levels in azotemia group and uremia group were remarkably higher than those in normal group respectively (P<0.05), and serum α 1-MG level in uremia group was significantly higher than that in azotemia group (P<0.01), while serum Ⅳ-C level in uremia group showed no obvious difference from that in azotemia group (P>0.05). Conclusion Serum Ⅳ-C and α 1-MG levels may be one of the laboratory parameters for the determination of chronic renal failure.

关 键 词：Ⅳ型胶原 Α1-微球蛋白 慢性肾功能不全 

分 类 号：R692.5[医药卫生—泌尿科学]