消痰散结方对裸鼠胃肿瘤中ICAM-1表达的影响  

Effect of Xiaotan Sanjie Recipe on Expression of ICAM-1 in Gastric Carcinoma

作　　者：王建平[1] 魏品康[1] 许玲[1] 

机构地区：[1]第二军医大学长征医院中医科,上海200003

出　　处：《辽宁中医杂志》2001年第8期498-499,共2页Liaoning Journal of Traditional Chinese Medicine

基　　金：上海市卫生局资助课题

摘　　要：观察消痰散结方对裸鼠胃癌组织中胃癌细胞粘附分子ICAM 1表达的影响。建立裸鼠MKN 4 5人胃癌模型 ,采用免疫组化S P法检测胃癌组织中ICAM 1的表达。结果 ,中药组胃癌组织中ICAM 1表达水平明显低于空白对照组。说明 ,消痰散结方抑制胃癌细胞转移的环节可能与影响粘附分子的表达 ,进而影响细胞的粘附性机制有关。Objective:To investigate effect of Xiaotan Sanjie Recipe on expression of ICAM-1 in Gastric Carcinoma.Methods:A transplantable ascites tumor model of MKN-45 human gastric carcinoma in nude mice was established,by using S-P immunohistochemical method with anti-ICAM-1 monoclonal antibody,the expression of ICAM-1 in Gastric Carcinoma was studied.Results:The expression of ICAM-1 in Gastric Carcinoma in Chinese medicine group was obviously lower than that in control group.Conclusions:By lowering expression of ICAM-1 in Gastric Carcinomatous cell with Xiaotan Sanjie Recipe,mechanism of adhension of gastric carcinomatous cell was affected.

关 键 词：消痰散结方 胃肿瘤 细胞间粘附分子 裸鼠 中医药治疗 ICAM-1 

分 类 号：R273.52[医药卫生—中西医结合] R285.5[医药卫生—中医肿瘤科]